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Tchem
PIP4K2C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Protein Summary
Description
May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354947
  • ENSP00000347032
  • ENSG00000166908
  • ENST00000422156
  • ENSP00000412035
  • ENST00000540759
  • ENSP00000439878
  • ENST00000550465
  • ENSP00000447390

Symbol
  • PIP5K2C
  • PIP5K2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
molecular function
0.93
kinase perturbation
0.88
histone modification site profile
0.74
interacting protein
0.74


Related Tools
Dark Kinase Knowledgebase
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The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
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The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.31   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.31   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
Chemical Tool
1-((1H-imidazol-2-yl)methyl)-3-(1-(2-chlorophenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-thiazolo[4,5-g]indazol-7-yl)urea
image for 1-((1H-imidazol-2-yl)methyl)-3-(1-(2-chlorophenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-thiazolo[4,5-g]indazol-7-yl)urea
Details:
  • ChEBI:  156469
  • Provider:  UNC-CH
  • Activity:  NA
  • Selectivity:  NA
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
2
2
80.9
1
1
0
1.4
56.4
body fat distribution
1
1
2
31.4
IGF-1 measurement
1
1
1
30.2
systolic blood pressure
1
1
1
29.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
80.9
0
1.4
56.4
body fat distribution
2
31.4
IGF-1 measurement
1
30.2
systolic blood pressure
1
29.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
VGNC:13339
467044
Mouse
MGI:2152214
117150
Rat
RGD:621711
140607
Dog
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
VGNC:44572
474417
Horse
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
VGNC:21464
100053518
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Mouse
Rat
Dog
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Horse
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TBX8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (134)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Intracellular signaling by second messengers
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Intracellular signaling by second messengers
Metabolism
Metabolism of lipids
Protein-Protein Interactions (123)
1 – 10 of 123
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999999665
p_ni:  3.35e-7
p_wrong:  1e-9
Score:  0.934
Data Source:  BioPlex,Reactome,STRINGDB
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.999998557
p_ni:  0.000001443
Data Source:  BioPlex
ATG4C
Tbio
Family:  Enzyme
Novelty:  0.04175533
p_int:  0.999986898
p_ni:  0.000013102
Data Source:  BioPlex
ARHGAP22
Tbio
Family:  Enzyme
Novelty:  0.13037853
p_int:  0.999903998
p_ni:  0.000095994
p_wrong:  8e-9
Data Source:  BioPlex
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.999882431
p_ni:  0.000117569
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.99982937
p_ni:  0.00017063
p_wrong:  1e-9
Score:  0.207
Data Source:  BioPlex,STRINGDB
EAF1
Tbio
Novelty:  0.81120425
p_int:  0.999734278
p_ni:  0.000265722
Data Source:  BioPlex
GPBP1L1
Tdark
Novelty:  0.69320833
p_int:  0.999711694
p_ni:  0.000288306
Data Source:  BioPlex
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.999702832
p_ni:  0.000297161
p_wrong:  8e-9
Data Source:  BioPlex
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.999678241
p_ni:  0.000321759
Data Source:  BioPlex
Publication Statistics
PubMed Score  9.31

PubMed score by year
PubTator Score  37.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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