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Tdark
FAM174A
Membrane protein FAM174A

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312637
  • ENSP00000307954
  • ENSG00000174132

Symbol
  • NS5ATP6
  • TMEM157
  • NS5ATP6
  • TMEM157
  • UNQ1912
  • HGS_RE408
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor binding site profile
0.68
transcription factor
0.67
small molecule perturbation
0.61
cell type or tissue
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.999999949
p_ni:  5.1e-8
Score:  0.191
Data Source:  BioPlex,STRINGDB
TMEM168
Tdark
Novelty:  0.89372034
p_int:  0.99999727
p_ni:  7.69e-7
p_wrong:  0.000001961
Score:  0.804
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.999990458
p_ni:  0.000009542
Data Source:  BioPlex
TAMM41
Tbio
Family:  Enzyme
Novelty:  0.06004824
p_int:  0.999032415
p_ni:  0.000967585
Data Source:  BioPlex
TTK
Tchem
Family:  Kinase
Novelty:  0.00447957
p_int:  0.998839059
p_ni:  0.001160941
Data Source:  BioPlex
SLC39A11
Tbio
Family:  Transporter
Novelty:  0.09770302
p_int:  0.997942812
p_ni:  0.002057188
Data Source:  BioPlex
COQ5
Tbio
Family:  Enzyme
Novelty:  0.04664953
p_int:  0.997471497
p_ni:  0.002528503
Score:  0.173
Data Source:  BioPlex,STRINGDB
NDUFB5
Tclin
Family:  Enzyme
Novelty:  0.0257403
p_int:  0.99710966
p_ni:  0.001721128
p_wrong:  0.001169212
Data Source:  BioPlex
TRAPPC5
Tdark
Novelty:  0.22558077
p_int:  0.99710966
p_ni:  0.001721128
p_wrong:  0.001169212
Data Source:  BioPlex
FAM118B
Tdark
Novelty:  0.48168976
p_int:  0.995971985
p_ni:  0.004028008
p_wrong:  7e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
17.6
bone density
1
1
1
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
17.6
bone density
1
3
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 174 member A
VGNC:3992
461970
Macaque
family with sequence similarity 174 member A
702300
Mouse
MGI:1914948
67698
Rat
RGD:1309973
301634
Dog
family with sequence similarity 174 member A
VGNC:40627
608799
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 174 member A
Macaque
family with sequence similarity 174 member A
Mouse
Rat
Dog
family with sequence similarity 174 member A
Publication Statistics
PubMed Score 3.22
PubMed score by year
PubTator Score 0.14
PubTator score by year
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Related Publications
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PMID
Year
Title