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Tbio
SETD6
N-lysine methyltransferase SETD6

Protein Summary
Description
Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity (PubMed:21131967). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity). This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219315
  • ENSP00000219315
  • ENSG00000103037
  • ENST00000310682
  • ENSP00000310082
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
virus perturbation
0.88
histone modification site profile
0.87
kinase perturbation
0.84
transcription factor binding site profile
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.99   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.99   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
1
1
0
2.5
69
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
0
2.5
69
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SET domain containing 6
VGNC:5917
739019
Macaque
SET domain containing 6
707353
Mouse
MGI:1913333
66083
Rat
RGD:1560538
291844
Dog
SET domain containing 6
VGNC:46057
487253
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SET domain containing 6
Macaque
SET domain containing 6
Mouse
Rat
Dog
SET domain containing 6
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TBK2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (47)
1 – 10 of 47
RPL36AL
Tbio
Novelty: 0.09336423
p_int: 0.999999955
p_ni: 3.6e-8
p_wrong: 1e-8
Score: 0.453
Data Source: BioPlex,STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.0007137
Score: 0.993
Data Source: Reactome,STRINGDB
NFKB1
Tclin
Family: TF
Novelty: 0.00198195
Score: 0.908
Data Source: Reactome,STRINGDB
NFKB2
Tchem
Family: TF
Novelty: 0.00366074
Score: 0.908
Data Source: Reactome,STRINGDB
SETD4
Tbio
Family: Epigenetic
Novelty: 0.1994878
Score: 0.806
Data Source: STRINGDB
SETD7
Tchem
Family: Epigenetic
Novelty: 0.00610155
Score: 0.642
Data Source: STRINGDB
PAK4
Tchem
Family: Kinase
Novelty: 0.0068821
Score: 0.597
Data Source: STRINGDB
SETD2
Tchem
Family: Epigenetic
Novelty: 0.00178899
Score: 0.589
Data Source: STRINGDB
GAMT
Tbio
Family: Enzyme
Novelty: 0.00656642
Score: 0.562
Data Source: STRINGDB
SMYD2
Tchem
Family: Epigenetic
Novelty: 0.0192516
Score: 0.559
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.99

PubMed score by year
PubTator Score  6.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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