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Tbio
FEZF2
Fez family zinc finger protein 2

Protein Summary
Description
Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283268
  • ENSP00000283268
  • ENSG00000153266
  • ENST00000475839
  • ENSP00000418804
  • ENST00000486811
  • ENSP00000418589

Symbol
  • FEZL
  • ZNF312
  • FEZ
  • TOF
  • FEZL
  • FKSG36
  • ZFP312
  • ZNF312
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
molecular function
0.67
tissue sample
0.65
PubMedID
0.64
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.46   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.46   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
1
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
3.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FEZ family zinc finger 2
VGNC:7970
470840
Macaque
FEZ family zinc finger 2
699851
Mouse
MGI:1859823
54713
Rat
RGD:1311068
305719
Dog
FEZ family zinc finger 2
VGNC:40829
476568
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FEZ family zinc finger 2
Macaque
FEZ family zinc finger 2
Mouse
Rat
Dog
FEZ family zinc finger 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TBJ5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (23)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (80)
1 – 10 of 80
TBR1
Tbio
Family: TF
Novelty: 0.00676736
Score: 0.88
Data Source: STRINGDB
SATB2
Tbio
Family: TF
Novelty: 0.00405935
Score: 0.853
Data Source: STRINGDB
CUX2
Tbio
Family: TF
Novelty: 0.02004476
Score: 0.742
Data Source: STRINGDB
NEUROG1
Tbio
Family: TF
Novelty: 0.00494095
Score: 0.714
Data Source: STRINGDB
SOX5
Tbio
Family: TF
Novelty: 0.00623121
Score: 0.71
Data Source: STRINGDB
OTP
Tbio
Family: TF
Novelty: 0.01535446
Score: 0.671
Data Source: STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.67
Data Source: STRINGDB
SIX3
Tbio
Family: TF
Novelty: 0.00599946
Score: 0.645
Data Source: STRINGDB
CDX1
Tbio
Family: TF
Novelty: 0.00815821
Score: 0.642
Data Source: STRINGDB
PAX6
Tbio
Family: TF
Novelty: 0.00064695
Score: 0.626
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.46

PubMed score by year
PubTator Score  1086.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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