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Tbio
FEZF2
Fez family zinc finger protein 2

Protein Summary
Description
Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283268
  • ENSP00000283268
  • ENSG00000153266
  • ENST00000475839
  • ENSP00000418804
  • ENST00000486811
  • ENSP00000418589

Symbol
  • FEZL
  • ZNF312
  • FEZ
  • TOF
  • FEZL
  • FKSG36
  • ZFP312
  • ZNF312
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
molecular function
0.67
tissue sample
0.65
PubMedID
0.64
virus perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.46   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.46   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
1
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
3.9
Gene Ontology Terms (23)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (80)
1 – 10 of 80
TBR1
Tbio
Family: TF
Novelty: 0.00676736
Score: 0.88
Data Source: STRINGDB
SATB2
Tbio
Family: TF
Novelty: 0.00405935
Score: 0.853
Data Source: STRINGDB
CUX2
Tbio
Family: TF
Novelty: 0.02004476
Score: 0.742
Data Source: STRINGDB
NEUROG1
Tbio
Family: TF
Novelty: 0.00494095
Score: 0.714
Data Source: STRINGDB
SOX5
Tbio
Family: TF
Novelty: 0.00623121
Score: 0.71
Data Source: STRINGDB
OTP
Tbio
Family: TF
Novelty: 0.01535446
Score: 0.671
Data Source: STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.67
Data Source: STRINGDB
SIX3
Tbio
Family: TF
Novelty: 0.00599946
Score: 0.645
Data Source: STRINGDB
CDX1
Tbio
Family: TF
Novelty: 0.00815821
Score: 0.642
Data Source: STRINGDB
PAX6
Tbio
Family: TF
Novelty: 0.00064695
Score: 0.626
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.46

PubMed score by year
PubTator Score  1086.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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