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Tbio
ETNPPL
Ethanolamine-phosphate phospho-lyase

Protein Summary
Description
Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296486
  • ENSP00000296486
  • ENSG00000164089
  • ENST00000411864
  • ENSP00000392269
  • ENST00000512646
  • ENSP00000427065

Symbol
  • AGXT2L1
  • AGXT2L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
histone modification site profile
0.72
cell type or tissue
0.63
protein domain
0.58
molecular function
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.1   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.1   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
3
78.1
low density lipoprotein cholesterol measurement
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
78.1
low density lipoprotein cholesterol measurement
1
1.1
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ethanolamine-phosphate phospho-lyase
VGNC:2997
461428
Macaque
ethanolamine-phosphate phospho-lyase
696880
Mouse
MGI:1919010
71760
Rat
RGD:1590098
687071
Cow
ethanolamine-phosphate phospho-lyase
VGNC:53712
515186
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ethanolamine-phosphate phospho-lyase
Macaque
ethanolamine-phosphate phospho-lyase
Mouse
Rat
Cow
ethanolamine-phosphate phospho-lyase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TBG4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PE
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PE
Protein-Protein Interactions (35)
1 – 10 of 35
ZC3HC1
Tbio
Novelty:  0.089692
p_int:  0.926561688
p_ni:  0.073438235
p_wrong:  7.7e-8
Score:  0.379
Data Source:  BioPlex,STRINGDB
HYKK
Tbio
Family:  Enzyme
Novelty:  0.11408577
Score:  0.935
Data Source:  STRINGDB
ETNK1
Tbio
Family:  Kinase
Novelty:  0.04817798
Score:  0.925
Data Source:  STRINGDB
CHKB
Tbio
Family:  Kinase
Novelty:  0.00862294
Score:  0.912
Data Source:  STRINGDB
ETNK2
Tbio
Family:  Kinase
Novelty:  0.13225627
Score:  0.907
Data Source:  STRINGDB
CHKA
Tchem
Family:  Kinase
Novelty:  0.00237839
Score:  0.905
Data Source:  STRINGDB
PHOSPHO1
Tchem
Family:  Enzyme
Novelty:  0.05458897
Score:  0.9
Data Source:  STRINGDB
PCYT2
Tbio
Family:  Enzyme
Novelty:  0.03267621
Score:  0.9
Data Source:  STRINGDB
LSMEM1
Tdark
Novelty:  15.71612903
Score:  0.603
Data Source:  STRINGDB
FAM107A
Tbio
Novelty:  0.03656395
Score:  0.594
Data Source:  STRINGDB
Publication Statistics
PubMed Score  12.10

PubMed score by year
PubTator Score  4.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer