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Tdark
PRXL2B
Prostamide/prostaglandin F synthase

Protein Summary
Description
Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378424
  • ENSP00000367681
  • ENSG00000157870
  • ENST00000378427
  • ENSP00000367684
  • ENST00000419916
  • ENSP00000394405

Symbol
  • C1orf93
  • FAM213B
  • C1orf93
  • FAM213B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
histone modification site profile
0.73
cellular component
0.7
tissue
0.68
small molecule perturbation
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.04   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.04   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
75.7
Pathways (7)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Protein-Protein Interactions (21)
1 – 10 of 21
NUCB1
Tchem
Novelty: 0.0040312
p_int: 0.999999771
p_ni: 2.29e-7
p_wrong: 1e-9
Score: 0.279
Data Source: BioPlex,STRINGDB
NARS
Tbio
Family: Enzyme
Novelty: 0.01124207
p_int: 0.956975816
p_ni: 0.043011926
p_wrong: 0.000012258
Score: 0.228
Data Source: BioPlex,STRINGDB
BCAT1
Tchem
Family: Enzyme
Novelty: 0.00616446
p_int: 0.915081602
p_ni: 0.084918397
p_wrong: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
p_int: 0.881452254
p_ni: 0.084391077
p_wrong: 0.034156669
Score: 0.239
Data Source: BioPlex,STRINGDB
LGALSL
Tbio
Novelty: 0.02633185
Score: 0.672
Data Source: STRINGDB
LSM14B
Tdark
Novelty: 0.31832554
Score: 0.636
Data Source: STRINGDB
ARHGEF10L
Tbio
Novelty: 0.56695323
Score: 0.634
Data Source: STRINGDB
ESRP2
Tbio
Novelty: 0.05084007
Score: 0.503
Data Source: STRINGDB
ESRP1
Tbio
Novelty: 0.02035464
Score: 0.491
Data Source: STRINGDB
COPS3
Tbio
Novelty: 0.04664225
Score: 0.478
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.04

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer