Tbio CNIH3 Protein cornichon homolog 3

Protein Summary

Description

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.

Uniprot Accession IDs

• Q8TBE1
• CNIH-3

Gene Name

• CNIH3

Ensembl ID

• ENST00000272133
• ENSP00000272133
• ENSG00000143786

Symbol

• CNIH-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.74
PubMedID	0.72
transcription factor binding site profile	0.59
histone modification site profile	0.53
tissue sample	0.5

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Protein Cornichon Homolog 3

Protein / Membrane Traffic Protein / Protein Cornichon Homolog 3

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Protein Cornichon Homolog 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.76   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.76   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0