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Tbio
UBA3
NEDD8-activating enzyme E1 catalytic subunit

Protein Classes
Protein Summary
Description
Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349511
  • ENSP00000340041
  • ENSG00000144744
  • ENST00000361055
  • ENSP00000354340

Symbol
  • UBE1C
  • NAE2
  • UBE1C
  • hUBA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.94
cell type or tissue
0.7
tissue sample
0.7
kinase perturbation
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.22   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.22   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like modifier activating enzyme 3
VGNC:7136
460496
Macaque
ubiquitin like modifier activating enzyme 3
696493
Mouse
MGI:1341217
22200
Rat
RGD:621084
117553
Dog
ubiquitin like modifier activating enzyme 3
VGNC:48038
476560
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like modifier activating enzyme 3
Macaque
ubiquitin like modifier activating enzyme 3
Mouse
Rat
Dog
ubiquitin like modifier activating enzyme 3
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TBC4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (17)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (398)
1 – 10 of 398
UBE2M
Tbio
Novelty: 0.02353106
p_int: 0.999938672
p_ni: 0.000061328
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ANKRD39
Tdark
Novelty: 8.68843298
p_int: 0.999785262
p_ni: 0.000214738
Data Source: BioPlex
ZBTB44
Tdark
Family: TF
Novelty: 0.75195191
p_int: 0.924153106
p_ni: 0.075846869
p_wrong: 2.6e-8
Score: 0.374
Data Source: BioPlex,STRINGDB
APIP
Tbio
Family: Enzyme
Novelty: 0.04661109
p_int: 0.849199475
p_ni: 0.150800524
p_wrong: 1e-9
Score: 0.587
Data Source: BioPlex,STRINGDB
NAE1
Tchem
Novelty: 0.0283623
p_int: 0.778184161
p_ni: 0.221815839
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NEDD8
Tbio
Novelty: 0.00305343
Score: 0.999
Data Source: Reactome,STRINGDB
UBE2F
Tbio
Novelty: 0.06951245
Score: 0.997
Data Source: Reactome,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.991
Data Source: STRINGDB
UBE2H
Tbio
Novelty: 0.03259425
Score: 0.989
Data Source: STRINGDB
CUL3
Tbio
Novelty: 0.0028737
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.22

PubMed score by year
PubTator Score  15.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer