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Tchem
UBA3
NEDD8-activating enzyme E1 catalytic subunit

Protein Summary
Description
Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349511
  • ENSP00000340041
  • ENSG00000144744
  • ENST00000361055
  • ENSP00000354340

Symbol
  • UBE1C
  • NAE2
  • UBE1C
  • hUBA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.94
cell type or tissue
0.7
tissue sample
0.7
kinase perturbation
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.85   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.85   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (398)
UBE2M
Tchem
Novelty:  0.02353106
p_int:  0.999938672
p_ni:  0.000061328
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.999785262
p_ni:  0.000214738
Data Source:  BioPlex
ZBTB44
Tdark
Family:  TF
Novelty:  0.75195191
p_int:  0.924153106
p_ni:  0.075846869
p_wrong:  2.6e-8
Score:  0.374
Data Source:  BioPlex,STRINGDB
APIP
Tbio
Family:  Enzyme
Novelty:  0.04661109
p_int:  0.849199475
p_ni:  0.150800524
p_wrong:  1e-9
Score:  0.587
Data Source:  BioPlex,STRINGDB
NAE1
Tchem
Novelty:  0.0283623
p_int:  0.778184161
p_ni:  0.221815839
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NEDD8
Tchem
Novelty:  0.00305343
Score:  0.999
Data Source:  Reactome,STRINGDB
UBE2F
Tbio
Novelty:  0.06951245
Score:  0.997
Data Source:  Reactome,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.991
Data Source:  STRINGDB
UBE2H
Tbio
Novelty:  0.03259425
Score:  0.989
Data Source:  STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.983
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
2
2
74.7
sex hormone-binding globulin measurement
3
2
3
57.6
diet measurement
1
1
1
29
mean corpuscular hemoglobin concentration
1
1
1
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
74.7
sex hormone-binding globulin measurement
3
57.6
diet measurement
1
29
mean corpuscular hemoglobin concentration
1
11.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like modifier activating enzyme 3
VGNC:7136
460496
Macaque
ubiquitin like modifier activating enzyme 3
696493
Mouse
MGI:1341217
22200
Rat
RGD:621084
117553
Dog
ubiquitin like modifier activating enzyme 3
VGNC:48038
476560
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like modifier activating enzyme 3
Macaque
ubiquitin like modifier activating enzyme 3
Mouse
Rat
Dog
ubiquitin like modifier activating enzyme 3
Publication Statistics
PubMed Score 18.85
PubMed score by year
PubTator Score 15.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title