Tchem UBA3 NEDD8-activating enzyme E1 catalytic subunit

Protein Summary

Description

Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TBC4
• A6NLB5
• A8K027
• O76088
• Q9NTU3

Gene Name

• UBA3

Ensembl ID

• ENST00000349511
• ENSP00000340041
• ENSG00000144744
• ENST00000361055
• ENSP00000354340

Symbol

• UBE1C
• NAE2
• UBE1C
• hUBA3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
molecular function	0.94
cell type or tissue	0.7
tissue sample	0.7
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Nedd8-activating Enzyme E1 Catalytic Subunit

Protein / Ligase / Nedd8-activating Enzyme E1 Catalytic Subunit

DTO Classes

Protein / Enzyme / Ligase / Nedd8-activating Enzyme E1 Catalytic Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.48   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.48   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0