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Tbio
SLC7A14
Probable cationic amino acid transporter

Protein Summary
Description
May be involved in arginine transport. This gene is predicted to encode a glycosylated, cationic amino acid transporter protein with 14 transmembrane domains. This gene is primarily expressed in skin fibroblasts, neural tissue, and primary endothelial cells and its protein is predicted to mediate lysosomal uptake of cationic amino acids. Mutations in this gene are associated with autosomal recessive retinitis pigmentosa. In mice, this gene is expressed in the photoreceptor layer of the retina where its expression increases over the course of retinal development and persists in the mature retina. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231706
  • ENSP00000231706
  • ENSG00000013293

Symbol
  • KIAA1613
  • PPP1R142
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.82
cell line
0.65
cell type or tissue
0.43
chemical
0.41
biological process
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.84   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.84   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
GOLM1
Tbio
Novelty:  0.00752112
p_int:  0.999996674
p_ni:  0.000003326
Data Source:  BioPlex
TMEM56
Tdark
Novelty:  0.75633366
p_int:  0.997928968
p_ni:  0.002002264
p_wrong:  0.000068768
Data Source:  BioPlex
CYB5R1
Tbio
Family:  Enzyme
Novelty:  0.07714146
p_int:  0.996048006
p_ni:  0.003951725
p_wrong:  2.69e-7
Data Source:  BioPlex
SLC35B2
Tbio
Family:  Transporter
Novelty:  0.01516638
p_int:  0.992373302
p_ni:  0.007616726
p_wrong:  0.000009972
Data Source:  BioPlex
TMEM120B
Tdark
Novelty:  1.46242586
p_int:  0.990489519
p_ni:  0.009509448
p_wrong:  0.000001033
Data Source:  BioPlex
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.988804412
p_ni:  0.011195588
Data Source:  BioPlex
GPR89A
Tbio
Family:  IC
Novelty:  0.06782776
p_int:  0.987991316
p_ni:  0.01200868
p_wrong:  4e-9
Data Source:  BioPlex
FAM162A
Tbio
Novelty:  0.03110847
p_int:  0.966891842
p_ni:  0.033108158
Data Source:  BioPlex
MGAT5
Tbio
Family:  Enzyme
Novelty:  0.00707747
p_int:  0.957465289
p_ni:  0.042534487
p_wrong:  2.25e-7
Data Source:  BioPlex
DOLK
Tbio
Family:  Enzyme
Novelty:  0.00664639
p_int:  0.955233813
p_ni:  0.031725071
p_wrong:  0.013041116
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
1
1
52.4
CCL2 measurement
1
1
0
1.3
38.8
fatty acid measurement
1
1
0
1.3
38.8
2
1
0
1.1
36.9
glomerular filtration rate
2
1
2
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
52.4
CCL2 measurement
0
1.3
38.8
fatty acid measurement
0
1.3
38.8
0
1.1
36.9
glomerular filtration rate
2
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 14
VGNC:12190
470994
Macaque
solute carrier family 7 member 14
696121
Mouse
MGI:3040688
241919
Rat
RGD:1594375
499587
Dog
solute carrier family 7 member 14
VGNC:46473
488161
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 14
Macaque
solute carrier family 7 member 14
Mouse
Rat
Dog
solute carrier family 7 member 14
Publication Statistics
PubMed Score 8.84
PubMed score by year
PubTator Score 3.42
PubTator score by year
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Related Publications
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PMID
Year
Title