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Tdark
THAP6
THAP domain-containing protein 6

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311638
  • ENSP00000309007
  • ENSG00000174796
  • ENST00000380837
  • ENSP00000370217
  • ENST00000507556
  • ENSP00000427651
  • ENST00000514480
  • ENSP00000423720
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
transcription factor binding site profile
0.74
cellular component
0.61
tissue sample
0.59
cell type or tissue
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.27   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.27   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
79.2
1
1
0
1.2
49.5
2
2
2
49.4
high density lipoprotein cholesterol measurement
1
1
1
21.5
self reported educational attainment
1
1
1
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
79.2
0
1.2
49.5
2
49.4
high density lipoprotein cholesterol measurement
1
21.5
self reported educational attainment
1
2.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
THAP domain containing 6
VGNC:12852
461247
Macaque
THAP domain containing 6
701834
Rat
RGD:1310094
305244
Dog
THAP domain containing 6
VGNC:47330
487811
Horse
THAP domain containing 6
VGNC:24070
100057374
Species
Name
OMA
EggNOG
Inparanoid
Chimp
THAP domain containing 6
Macaque
THAP domain containing 6
Rat
Dog
THAP domain containing 6
Horse
THAP domain containing 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TBB0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (18)
1 – 10 of 18
FBXO47
Tdark
Novelty:  0.26075359
Score:  0.697
Data Source:  STRINGDB
CALHM4
Tdark
Family:  IC
Novelty:  2.79788039
Score:  0.676
Data Source:  STRINGDB
THAP8
Tdark
Family:  TF
Novelty:  3.10152067
Score:  0.669
Data Source:  STRINGDB
EEF1AKMT1
Tdark
Family:  Enzyme
Novelty:  0.22249584
Score:  0.667
Data Source:  STRINGDB
PTRH1
Tdark
Family:  Enzyme
Novelty:  0.20240403
Score:  0.573
Data Source:  STRINGDB
RPL7L1
Tdark
Novelty:  0.78428937
Score:  0.571
Data Source:  STRINGDB
THAP10
Tdark
Family:  TF
Novelty:  1.06994665
Score:  0.559
Data Source:  STRINGDB
TMED5
Tdark
Novelty:  0.32104091
Score:  0.544
Data Source:  STRINGDB
UGT3A1
Tdark
Family:  Enzyme
Novelty:  0.21988583
Score:  0.523
Data Source:  STRINGDB
UGT3A2
Tbio
Family:  Enzyme
Novelty:  0.35904542
Score:  0.523
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.27

PubMed score by year
PubTator Score  0.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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