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Tbio
ITFG1
T-cell immunomodulatory protein

Protein Summary
Description
Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320640
  • ENSP00000319918
  • ENSG00000129636

Symbol
  • LNKN-1
  • TIP
  • TIP
  • CDA08
  • LNKN-1
  • 2310047C21Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor perturbation
0.91
disease perturbation
0.87
virus perturbation
0.79
histone modification site profile
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.75   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.75   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
59.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
59.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin alpha FG-GAP repeat containing 1
VGNC:5825
465149
Macaque
integrin alpha FG-GAP repeat containing 1
716435
Mouse
MGI:106419
71927
Rat
RGD:619898
171083
Dog
integrin alpha FG-GAP repeat containing 1
VGNC:42118
478141
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin alpha FG-GAP repeat containing 1
Macaque
integrin alpha FG-GAP repeat containing 1
Mouse
Rat
Dog
integrin alpha FG-GAP repeat containing 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TB96-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (32)
1 – 10 of 32
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.971946471
p_ni:  0.028053529
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.959826838
p_ni:  0.040173162
Data Source:  BioPlex
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.874383104
p_ni:  0.125616896
Data Source:  BioPlex
CEACAM21
Tdark
Novelty:  0.46116153
p_int:  0.849836449
p_ni:  0.15016355
Data Source:  BioPlex
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.819382594
p_ni:  0.180617406
Data Source:  BioPlex
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.819347027
p_ni:  0.180652973
Data Source:  BioPlex
LSMEM2
Tdark
Novelty:  43
p_int:  0.766823167
p_ni:  0.233176833
Data Source:  BioPlex
TIPIN
Tbio
Novelty:  0.03919376
Score:  0.768
Data Source:  STRINGDB
LNPK
Tbio
Novelty:  0.07736762
Score:  0.714
Data Source:  STRINGDB
TM7SF3
Tbio
Novelty:  0.12188681
Score:  0.664
Data Source:  STRINGDB
Publication Statistics
PubMed Score  51.75

PubMed score by year
PubTator Score  11.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer