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Tbio
HMGCLL1
3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic

Protein Classes
Protein Summary
Description
Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274901
  • ENSP00000274901
  • ENSG00000146151
  • ENST00000308161
  • ENSP00000309737
  • ENST00000370852
  • ENSP00000359889
  • ENST00000398661
  • ENSP00000381654

Symbol
  • er-cHL
  • bA418P12.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
tissue sample
0.69
cellular component
0.61
histone modification site profile
0.52
cell line
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.8   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.8   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (10)
Ketone body metabolism (R-HSA-74182)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ketone body metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of Ketone Bodies
Name
Explore in Pharos
Explore in Source
Ketone body metabolism
Metabolism
Metabolism of lipids
Synthesis of Ketone Bodies
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (71)
1 – 10 of 71
HMGCL
Tbio
Family: Enzyme
Novelty: 0.03613197
p_int: 0.999872698
p_ni: 0.000127302
Score: 0.878
Data Source: BioPlex,STRINGDB
VPS13C
Tbio
Novelty: 0.09280821
p_int: 0.934149215
p_ni: 0.065850785
Score: 0.345
Data Source: BioPlex,STRINGDB
AUH
Tbio
Family: Enzyme
Novelty: 0.00961733
Score: 0.959
Data Source: STRINGDB
ACAA2
Tbio
Family: Enzyme
Novelty: 0.02112232
Score: 0.956
Data Source: STRINGDB
OXCT1
Tbio
Family: Enzyme
Novelty: 0.0035774
Score: 0.953
Data Source: STRINGDB
ACAA1
Tbio
Family: Enzyme
Novelty: 0.00482727
Score: 0.951
Data Source: STRINGDB
ACAT2
Tchem
Family: Enzyme
Novelty: 0.01744566
Score: 0.951
Data Source: STRINGDB
ACAT1
Tchem
Family: Enzyme
Novelty: 0.01281956
Score: 0.942
Data Source: STRINGDB
OXCT2
Tbio
Family: Enzyme
Novelty: 0.10124725
Score: 0.928
Data Source: STRINGDB
HMGCS1
Tchem
Family: Enzyme
Novelty: 0.01850134
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.80

PubMed score by year
PubTator Score  1.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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