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Tbio
PUM2
Pumilio homolog 2

Protein Summary
Description
Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338086
  • ENSP00000338173
  • ENSG00000055917
  • ENST00000361078
  • ENSP00000354370
  • ENST00000403432
  • ENSP00000385992

Symbol
  • KIAA0235
  • PUMH2
  • PUMH2
  • PUML2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.97
ligand (protein) perturbation
0.83
microRNA
0.8
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.12   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.12   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
1
1
28.8
apolipoprotein A 1 measurement
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
28.8
apolipoprotein A 1 measurement
1
8.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pumilio RNA binding family member 2
VGNC:6396
459053
Macaque
pumilio RNA binding family member 2
701782
Mouse
MGI:1931751
80913
Rat
RGD:1311024
298874
Dog
pumilio RNA binding family member 2
VGNC:45207
607618
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pumilio RNA binding family member 2
Macaque
pumilio RNA binding family member 2
Mouse
Rat
Dog
pumilio RNA binding family member 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TB72-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (128)
1 – 10 of 128
LARP4B
Tbio
Novelty: 0.11363794
p_int: 0.99999407
p_ni: 0.00000593
Score: 0.15
Data Source: BioPlex,STRINGDB
CLASRP
Tbio
Novelty: 0.00582947
p_int: 0.999972005
p_ni: 0.000027793
p_wrong: 2.03e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.999971777
p_ni: 0.000028053
p_wrong: 1.7e-7
Score: 0.711
Data Source: BioPlex,STRINGDB
RBFOX2
Tbio
Novelty: 0.00856339
p_int: 0.999932096
p_ni: 0.000067891
p_wrong: 1.3e-8
Score: 0.673
Data Source: BioPlex,STRINGDB
CELF5
Tbio
Novelty: 0.04733002
p_int: 0.999802818
p_ni: 0.00019718
p_wrong: 2e-9
Score: 0.606
Data Source: BioPlex,STRINGDB
DAZ2
Tbio
p_int: 0.999671962
p_ni: 0.00032361
p_wrong: 0.000004428
Data Source: BioPlex
STRBP
Tbio
Novelty: 0.00919158
p_int: 0.99944378
p_ni: 0.000555369
p_wrong: 8.51e-7
Score: 0.727
Data Source: BioPlex,STRINGDB
ILF2
Tbio
Novelty: 0.01598188
p_int: 0.999303954
p_ni: 0.000694887
p_wrong: 0.000001159
Score: 0.686
Data Source: BioPlex,STRINGDB
CDX1
Tbio
Family: TF
Novelty: 0.00815821
p_int: 0.998949936
p_ni: 0.001049746
p_wrong: 3.18e-7
Score: 0.399
Data Source: BioPlex,STRINGDB
LITAF
Tbio
Family: TF
Novelty: 0.0097203
p_int: 0.998076275
p_ni: 0.000950164
p_wrong: 0.000973561
Data Source: BioPlex
Publication Statistics
PubMed Score  61.12

PubMed score by year
PubTator Score  29.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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