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Tbio
SLC35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

Protein Summary
Description
Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393812
  • ENSP00000377401
  • ENSG00000157593
  • ENST00000537814
  • ENSP00000440340
  • ENST00000538577
  • ENSP00000443845
  • ENST00000615337
  • ENSP00000480681
  • ENST00000619636
  • ENSP00000483181

Symbol
  • PAPST1
  • SLL
  • PAPST1
  • UGTrel4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
biological process
0.84
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.8
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.02   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.02   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.998857279
p_ni:  0.00114272
Data Source:  BioPlex
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
p_int:  0.998738888
p_ni:  0.001261062
p_wrong:  5e-8
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.998700078
p_ni:  0.001294438
p_wrong:  0.000005484
Data Source:  BioPlex
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.995193402
p_ni:  0.004806595
p_wrong:  2e-9
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.993480112
p_ni:  0.006519824
p_wrong:  6.4e-8
Data Source:  BioPlex
SLC7A14
Tbio
Family:  Transporter
Novelty:  0.1613451
p_int:  0.992373302
p_ni:  0.007616726
p_wrong:  0.000009972
Data Source:  BioPlex
SYP
Tbio
Novelty:  0.00021543
p_int:  0.991311263
p_ni:  0.008678446
p_wrong:  0.000010291
Score:  0.167
Data Source:  BioPlex,STRINGDB
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.987436649
p_ni:  0.012563346
p_wrong:  5e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.985559191
p_ni:  0.014440802
p_wrong:  7e-9
Score:  0.17
Data Source:  BioPlex,STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.974852134
p_ni:  0.023622081
p_wrong:  0.001525786
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Glycosaminoglycan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Glycosaminoglycan metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
85
mean corpuscular volume
1
2
2
83.5
4
2
3
1.2
76.8
monocyte percentage of leukocytes
2
1
2
70.5
red blood cell distribution width
2
3
3
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
85
mean corpuscular volume
2
83.5
3
1.2
76.8
monocyte percentage of leukocytes
2
70.5
red blood cell distribution width
3
68.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921086
73836
Rat
RGD:1565318
501103
Dog
solute carrier family 35 member B2
VGNC:46365
481819
Horse
solute carrier family 35 member B2
VGNC:23166
100067750
Cow
solute carrier family 35 member B2
VGNC:34824
767848
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
solute carrier family 35 member B2
Horse
solute carrier family 35 member B2
Cow
solute carrier family 35 member B2
Publication Statistics
PubMed Score 65.02
PubMed score by year
PubTator Score 106.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title