Tbio SLC35B2 Adenosine 3'-phospho 5'-phosphosulfate transporter 1

Protein Summary

Description

Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8TB61
• B4DDM2
• B4DDU9
• F5H7Y9
• Q2VY06
• Q53GA3
• Q5T9W1
• Q5T9W2
• Q7Z2G3
• Q8NBK6
• Q96AR6

Gene Name

• SLC35B2

Ensembl ID

• ENST00000393812
• ENSP00000377401
• ENSG00000157593
• ENST00000537814
• ENSP00000440340
• ENST00000538577
• ENSP00000443845
• ENST00000615337
• ENSP00000480681
• ENST00000619636
• ENSP00000483181

Symbol

• PAPST1
• SLL
• PAPST1
• UGTrel4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.99
biological process	0.84
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.8
molecular function	0.76

Protein Classes

PANTHER Classes

Protein / Transporter / Adenosine 3'-phospho 5'-phosphosulfate Transporter 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc35 Family Of Nucleotide Sugar Transporters / Adenosine 3'-phospho 5'-phosphosulfate Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.51   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.51   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0