Tchem DEPTOR DEP domain-containing mTOR-interacting protein

Protein Summary

Description

Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.

Uniprot Accession IDs

• Q8TB45
• B2RCL9
• B4DN97
• E7EV87
• Q96EQ1
• Q9H0R7
• Q9H894
• Q9HA07

Gene Name

• DEPTOR

Ensembl ID

• ENST00000286234
• ENSP00000286234
• ENSG00000155792
• ENST00000523492
• ENSP00000430457

Symbol

• DEPDC6
• DEP.6
• DEPDC6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
transcription factor binding site profile	0.86
small molecule perturbation	0.78
virus perturbation	0.68
PubMedID	0.67

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Dep Domain-containing Mtor-interacting Protein

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Dep Domain-containing Mtor-interacting Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.21   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 246   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.21   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0