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Tbio
NUBPL
Iron-sulfur protein NUBPL

Protein Summary
Description
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits. This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic complex located in the inner mitochondrial membrane. Mutations in this gene cause mitochondrial complex I deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281081
  • ENSP00000281081
  • ENSG00000151413
  • ENST00000547839
  • ENSP00000449918

Symbol
  • C14orf127
  • IND1
  • huInd1
  • MC1DN21
  • C14orf127
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
molecular function
0.86
virus perturbation
0.83
transcription factor
0.71
transcription factor binding site profile
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.06   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.06   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
24.5
1
1
1
24.5
birth weight
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
24.5
1
24.5
birth weight
1
15.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleotide binding protein like
VGNC:8355
467418
Macaque
nucleotide binding protein like
717011
Mouse
MGI:1924076
76826
Rat
RGD:1307232
299008
Dog
nucleotide binding protein like
VGNC:44019
609340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleotide binding protein like
Macaque
nucleotide binding protein like
Mouse
Rat
Dog
nucleotide binding protein like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TB37-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (56)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (121)
1 – 10 of 121
DNAJB11
Tbio
Novelty:  0.02588745
p_int:  0.964817152
p_ni:  0.035182848
Score:  0.403
Data Source:  BioPlex,STRINGDB
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
Score:  0.971
Data Source:  STRINGDB
NDUFS8
Tclin
Family:  Enzyme
Novelty:  0.02408724
Score:  0.962
Data Source:  STRINGDB
NDUFS2
Tclin
Family:  Enzyme
Novelty:  0.02347576
Score:  0.961
Data Source:  STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
Score:  0.96
Data Source:  STRINGDB
NDUFV2
Tclin
Family:  Enzyme
Novelty:  0.02240263
Score:  0.96
Data Source:  STRINGDB
NDUFAF2
Tclin
Novelty:  0.04815608
Score:  0.958
Data Source:  STRINGDB
NDUFS3
Tclin
Family:  Enzyme
Novelty:  0.01968313
Score:  0.955
Data Source:  STRINGDB
NDUFV1
Tclin
Family:  Enzyme
Novelty:  0.01929835
Score:  0.955
Data Source:  STRINGDB
NDUFS4
Tclin
Family:  Enzyme
Novelty:  0.00787292
Score:  0.95
Data Source:  STRINGDB
Publication Statistics
PubMed Score  101.06

PubMed score by year
PubTator Score  25.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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