Tbio NUBPL Iron-sulfur protein NUBPL

Protein Summary

Description

Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits. This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic complex located in the inner mitochondrial membrane. Mutations in this gene cause mitochondrial complex I deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q8TB37
• B4DHZ1
• Q86TZ4
• Q9H9M2

Gene Name

• NUBPL

Ensembl ID

• ENST00000281081
• ENSP00000281081
• ENSG00000151413
• ENST00000547839
• ENSP00000449918

Symbol

• C14orf127
• IND1
• huInd1
• MC1DN21
• C14orf127

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
molecular function	0.86
virus perturbation	0.83
transcription factor	0.71
transcription factor binding site profile	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.42   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.42   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0