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Tbio
RIN3
Ras and Rab interactor 3

Protein Summary
Description
Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216487
  • ENSP00000216487
  • ENSG00000100599
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
PubMedID
0.72
phenotype
0.71
histone modification site profile
0.68
transcription factor binding site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.02   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.02   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
RAB5B
Tbio
Family:  Enzyme
Novelty:  0.02653775
Score:  0.983
Data Source:  STRINGDB
RAB5A
Tbio
Family:  Enzyme
Novelty:  0.00111347
Score:  0.966
Data Source:  STRINGDB
CD2AP
Tbio
Novelty:  0.00603034
Score:  0.947
Data Source:  STRINGDB
RAB5C
Tbio
Family:  Enzyme
Novelty:  0.02952779
Score:  0.944
Data Source:  STRINGDB
RAB31
Tbio
Family:  Enzyme
Novelty:  0.03673084
Score:  0.942
Data Source:  Reactome,STRINGDB
GDI2
Tbio
Novelty:  0.02861013
Score:  0.9
Data Source:  Reactome,STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
Score:  0.9
Data Source:  Reactome,STRINGDB
GDI1
Tbio
Novelty:  0.01710945
Score:  0.9
Data Source:  Reactome,STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
Score:  0.9
Data Source:  Reactome,STRINGDB
BIN1
Tbio
Novelty:  0.00312612
Score:  0.889
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
3
5
96.6
neutrophil count
3
4
4
94.8
eosinophil count
3
3
4
92.9
myeloid white cell count
2
2
2
91.7
monocyte count
2
2
2
91.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
5
96.6
neutrophil count
4
94.8
eosinophil count
4
92.9
myeloid white cell count
2
91.7
monocyte count
2
91.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras and Rab interactor 3
VGNC:3338
740239
Macaque
Ras and Rab interactor 3
698125
Mouse
MGI:2385708
217835
Rat
RGD:1305849
314397
Dog
Ras and Rab interactor 3
VGNC:45588
490590
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras and Rab interactor 3
Macaque
Ras and Rab interactor 3
Mouse
Rat
Dog
Ras and Rab interactor 3
Publication Statistics
PubMed Score 18.02
PubMed score by year
PubTator Score 7.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title