Tbio MUC7 Mucin-7

Protein Summary

Description

May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili. This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• Q8TAX7
• Q9UCD7
• Q9UCD8
• MUC-7

Gene Name

• MUC7

Ensembl ID

• ENST00000304887
• ENSP00000302021
• ENSG00000171195
• ENST00000413702
• ENSP00000407422
• ENST00000456088
• ENSP00000400585

Symbol

• MG2
• MG2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.5
cellular component	0.49
trait	0.46
disease	0.44
biological term	0.43

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.25   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.25   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
diabetic nephropathy	EFO_0000401	1	1	0	32.4	2.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
diabetic nephropathy	EFO_0000401	0	32.4	2.2

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Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mucin 7, secreted		742062
Macaque	mucin 7, secreted [Source:HGNC Symbol;Acc:HGNC:7518]
Dog	mucin-7-like		102153116

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mucin 7, secreted
Macaque	mucin 7, secreted [Source:HGNC Symbol;Acc:HGNC:7518]
Dog	mucin-7-like

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q8TAX7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)

Reactome (15)

KEGG (1)

C-type lectin receptors (CLRs) (R-HSA-5621481)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Reactome	Dectin-2 family	29 targets	R-HSA-5621480
Reactome	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Reactome	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Reactome	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Name	Explore in Pharos	Explore in Source
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Dectin-2 family	29 targets	R-HSA-5621480
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Gene Ontology Terms (9)

Components (5)

Processes (4)

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10

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GO Term	Evidence	Assigned by
other organism cell membrane	Inferred from Direct Assay (IDA)	UniProtKB
other organism cytoplasm	Inferred from Direct Assay (IDA)	UniProtKB
extracellular exosome	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
Golgi lumen	Traceable Author Statement (TAS)	Reactome
plasma membrane	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (102)

Explore Interacting Targets

1 – 10 of 102

• See Interactions on String-DB

FRMD1

Tdark

Novelty:  0.96833141

p_int:  0.999999451

p_ni:  5.47e-7

p_wrong:  2e-9

Data Source:  BioPlex

CAMK1D

Tchem

Family:  Kinase

Novelty:  0.0274233

p_int:  0.999918014

p_ni:  0.00002396

p_wrong:  0.000058026

Score:  0.217

Data Source:  BioPlex,STRINGDB

KIR2DS2

Tdark

p_int:  0.999895093

p_ni:  0.000038554

p_wrong:  0.000066353

Data Source:  BioPlex

ZNF491

Tdark

Family:  TF

Novelty:  4.75862069

p_int:  0.999871982

p_ni:  0.000047766

p_wrong:  0.000080252

Score:  0.188

Data Source:  BioPlex,STRINGDB

SLIRP

Tbio

Novelty:  0.04630917

p_int:  0.99974624

p_ni:  0.000203117

p_wrong:  0.000050642

Data Source:  BioPlex

NPB

Tdark

Novelty:  0.00936692

p_int:  0.999733904

p_ni:  0.000220375

p_wrong:  0.000045721

Data Source:  BioPlex

UCP2

Tbio

Novelty:  0.00083843

p_int:  0.999484948

p_ni:  0.000047632

p_wrong:  0.00046742

Score:  0.205

Data Source:  BioPlex,STRINGDB

RCAN2

Tbio

Novelty:  0.00174006

p_int:  0.917185071

p_ni:  0.000330789

p_wrong:  0.082484139

Score:  0.173

Data Source:  BioPlex,STRINGDB

GTF2B

Tbio

Novelty:  0.00179492

p_int:  0.895694121

p_ni:  0.000108781

p_wrong:  0.104197098

Score:  0.212

Data Source:  BioPlex,STRINGDB

JAK2

Tclin

Family:  Kinase

Novelty:  0.00022894

p_int:  0.895337304

p_ni:  0.000011269

p_wrong:  0.104651427

Data Source:  BioPlex

Publication Statistics

PubMed Score  137.25

PubMed score by year

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PubTator Score  913.33

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Asthma
Complete proteome
Direct protein sequencing
Glycoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
diabetic nephropathy