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Tbio
MUC7
Mucin-7

Protein Summary
Description
May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili. This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304887
  • ENSP00000302021
  • ENSG00000171195
  • ENST00000413702
  • ENSP00000407422
  • ENST00000456088
  • ENSP00000400585

Symbol
  • MG2
  • MG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.5
cellular component
0.49
trait
0.46
disease
0.44
biological term
0.43


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.25   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.25   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diabetic nephropathy
1
1
0
32.4
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diabetic nephropathy
0
32.4
2.2
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mucin 7, secreted
742062
Macaque
mucin 7, secreted [Source:HGNC Symbol;Acc:HGNC:7518]
Dog
mucin-7-like
102153116
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mucin 7, secreted
Macaque
mucin 7, secreted [Source:HGNC Symbol;Acc:HGNC:7518]
Dog
mucin-7-like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TAX7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Reactome
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Protein-Protein Interactions (102)
1 – 10 of 102
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.999999451
p_ni:  5.47e-7
p_wrong:  2e-9
Data Source:  BioPlex
CAMK1D
Tchem
Family:  Kinase
Novelty:  0.0274233
p_int:  0.999918014
p_ni:  0.00002396
p_wrong:  0.000058026
Score:  0.217
Data Source:  BioPlex,STRINGDB
KIR2DS2
Tdark
p_int:  0.999895093
p_ni:  0.000038554
p_wrong:  0.000066353
Data Source:  BioPlex
ZNF491
Tdark
Family:  TF
Novelty:  4.75862069
p_int:  0.999871982
p_ni:  0.000047766
p_wrong:  0.000080252
Score:  0.188
Data Source:  BioPlex,STRINGDB
SLIRP
Tbio
Novelty:  0.04630917
p_int:  0.99974624
p_ni:  0.000203117
p_wrong:  0.000050642
Data Source:  BioPlex
NPB
Tdark
Novelty:  0.00936692
p_int:  0.999733904
p_ni:  0.000220375
p_wrong:  0.000045721
Data Source:  BioPlex
UCP2
Tbio
Novelty:  0.00083843
p_int:  0.999484948
p_ni:  0.000047632
p_wrong:  0.00046742
Score:  0.205
Data Source:  BioPlex,STRINGDB
RCAN2
Tbio
Novelty:  0.00174006
p_int:  0.917185071
p_ni:  0.000330789
p_wrong:  0.082484139
Score:  0.173
Data Source:  BioPlex,STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
p_int:  0.895694121
p_ni:  0.000108781
p_wrong:  0.104197098
Score:  0.212
Data Source:  BioPlex,STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
p_int:  0.895337304
p_ni:  0.000011269
p_wrong:  0.104651427
Data Source:  BioPlex
Publication Statistics
PubMed Score  137.25

PubMed score by year
PubTator Score  913.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer