Protein Summary
May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili. This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014]
- ENST00000304887
- ENSP00000302021
- ENSG00000171195
- ENST00000413702
- ENSP00000407422
- ENST00000456088
- ENSP00000400585
- MG2
- MG2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor | 0.5 | ||
cellular component | 0.49 | ||
trait | 0.46 | ||
disease | 0.44 | ||
biological term | 0.43 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.25 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.25 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (102)
CAMK1D
Family: Kinase
Novelty: 0.0274233
p_int: 0.999918014
p_ni: 0.00002396
p_wrong: 0.000058026
Score: 0.217
Data Source: BioPlex,STRINGDB
ZNF491
Family: TF
Novelty: 4.75862069
p_int: 0.999871982
p_ni: 0.000047766
p_wrong: 0.000080252
Score: 0.188
Data Source: BioPlex,STRINGDB
SLIRP
Novelty: 0.04630917
p_int: 0.99974624
p_ni: 0.000203117
p_wrong: 0.000050642
Data Source: BioPlex
NPB
Novelty: 0.00936692
p_int: 0.999733904
p_ni: 0.000220375
p_wrong: 0.000045721
Data Source: BioPlex
UCP2
Novelty: 0.00083843
p_int: 0.999484948
p_ni: 0.000047632
p_wrong: 0.00046742
Score: 0.205
Data Source: BioPlex,STRINGDB
RCAN2
Novelty: 0.00174006
p_int: 0.917185071
p_ni: 0.000330789
p_wrong: 0.082484139
Score: 0.173
Data Source: BioPlex,STRINGDB
GTF2B
Novelty: 0.00179492
p_int: 0.895694121
p_ni: 0.000108781
p_wrong: 0.104197098
Score: 0.212
Data Source: BioPlex,STRINGDB
JAK2
Family: Kinase
Novelty: 0.00022894
p_int: 0.895337304
p_ni: 0.000011269
p_wrong: 0.104651427
Data Source: BioPlex
Nearest Tclin Targets
Pathways (16)
Reactome (15)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | Dectin-2 family | ||||
Reactome | Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Reactome | Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Reactome | Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
C-type lectin receptors (CLRs) | ||||
Dectin-2 family | ||||
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Components (5)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 32.4 | 2.2 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 32.4 | 2.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | mucin 7, secreted | 742062 | ||||||
Macaque | mucin 7, secreted [Source:HGNC Symbol;Acc:HGNC:7518] | |||||||
Dog | mucin-7-like | 102153116 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | mucin 7, secreted | |||||
Macaque | mucin 7, secreted [Source:HGNC Symbol;Acc:HGNC:7518] | |||||
Dog | mucin-7-like | |||||
Publication Statistics
PubMed Score 137.25
PubMed score by year
PubTator Score 913.33
PubTator score by year
Related Publications
Text Mined References (46)
GeneRif Annotations (25)
Items per page:
0 of 0
PMID | Year | Title |
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