Tbio STOML3 Stomatin-like protein 3

Protein Summary

Description

Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.

Uniprot Accession IDs

• Q8TAV4
• B4E285
• Q5JS35
• SLP-3

Gene Name

• STOML3

Ensembl ID

• ENST00000379631
• ENSP00000368952
• ENSG00000133115
• ENST00000423210
• ENSP00000401989

Symbol

• SRO
• Epb7.2l

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.58
gene perturbation	0.56
microRNA	0.56
virus perturbation	0.55
cell type or tissue	0.51

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Stomatin-like Protein 3

Protein / ... / Protease Inhibitor / Stomatin-like Protein 3

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Stomatin-like Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.9   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.9   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0