Tbio NKX2-3 Homeobox protein Nkx-2.3

Protein Summary

Description

Transcription factor. This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q8TAU0
• B4DUZ4
• Q9NYS6

Gene Name

• NKX2-3

Ensembl ID

• ENST00000344586
• ENSP00000342828
• ENSG00000119919

Symbol

• NKX23
• NKX2C
• CSX3
• NK2.3
• NKX2C
• NKX2.3
• NKX4-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.87
phenotype	0.82
gene perturbation	0.62
PubMedID	0.6
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Homeobox Protein Nkx-2.3

Protein / Nucleic Acid Binding / Dna Binding Protein / Homeobox Protein Nkx-2.3

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Homeobox Protein Nkx-2.3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.14   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.14   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0