Tbio NPLOC4 Nuclear protein localization protein 4 homolog

Protein Summary

Description

The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).

Uniprot Accession IDs

• Q8TAT6
• Q8N3J1
• Q9H8V2
• Q9H964
• Q9NWR5
• Q9P229
• Protein NPL4

Gene Name

• NPLOC4

Ensembl ID

• ENST00000331134
• ENSP00000331487
• ENSG00000182446
• ENST00000374747
• ENSP00000363879

Symbol

• KIAA1499
• NPL4
• NPL4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
protein domain	0.85
interacting protein	0.73
virus perturbation	0.72
transcription factor binding site profile	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.38   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.38   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0