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Tbio
FGFBP3
Fibroblast growth factor-binding protein 3

Protein Summary
Description
Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311575
  • ENSP00000339067
  • ENSG00000174721

Symbol
  • C10orf13
  • FGF-BP3
  • C10orf13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
transcription factor
0.56
histone modification site profile
0.48
tissue
0.47
microRNA
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
93.6
1
1
0
1.3
78.4
alkaline phosphatase measurement
2
2
1
6.5
70.1
testosterone measurement
2
2
2
62
neutrophil count
2
2
2
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
93.6
0
1.3
78.4
alkaline phosphatase measurement
1
6.5
70.1
testosterone measurement
2
62
neutrophil count
2
56.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor binding protein 3
VGNC:12332
739381
Mouse
MGI:1919764
72514
Rat
RGD:1560326
499349
Dog
fibroblast growth factor binding protein 3
VGNC:40855
100855624
Cow
fibroblast growth factor binding protein 3
VGNC:28984
615980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor binding protein 3
Mouse
Rat
Dog
fibroblast growth factor binding protein 3
Cow
fibroblast growth factor binding protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TAT2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
FGFR2 ligand binding and activation (R-HSA-190241)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR2 ligand binding and activation
Reactome
FGFR2b ligand binding and activation
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Reactome
Signaling by FGFR2
Name
Explore in Pharos
Explore in Source
FGFR2 ligand binding and activation
FGFR2b ligand binding and activation
Signal Transduction
Signaling by FGFR
Signaling by FGFR2
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
MGI
Protein-Protein Interactions (20)
1 – 10 of 20
FGF10
Tbio
Novelty:  0.00217451
Score:  0.91
Data Source:  STRINGDB
FGF1
Tchem
Novelty:  0.00055979
Score:  0.908
Data Source:  STRINGDB
FGF2
Tchem
Novelty:  0.00007856
Score:  0.904
Data Source:  STRINGDB
FGF3
Tbio
Novelty:  0.00474087
Score:  0.9
Data Source:  STRINGDB
FGF7
Tbio
Novelty:  0.00083346
Score:  0.9
Data Source:  STRINGDB
FGF22
Tbio
Novelty:  0.0553003
Score:  0.9
Data Source:  STRINGDB
LRCH1
Tbio
Novelty:  0.0923291
Score:  0.711
Data Source:  STRINGDB
HDHD3
Tdark
Family:  Enzyme
Novelty:  0.51499634
Score:  0.543
Data Source:  STRINGDB
BTBD9
Tbio
Novelty:  0.02793632
Score:  0.503
Data Source:  STRINGDB
PIR
Tchem
Novelty:  0.00327695
Score:  0.466
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.54

PubMed score by year
PubTator Score  2.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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