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Tdark
SUN3
SUN domain-containing protein 3

Protein Summary
Description
As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297325
  • ENSP00000297325
  • ENSG00000164744
  • ENST00000395572
  • ENSP00000378939
  • ENST00000412142
  • ENSP00000410204
  • ENST00000438771
  • ENSP00000409077

Symbol
  • SUNC1
  • SUNC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
cellular component
0.52
cell type or tissue
0.49
tissue
0.43
phenotype
0.38


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.1   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.1   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0