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Tbio
ZNF420
Zinc finger protein 420

Protein Summary
Description
May be involved in transcriptional regulation. The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304239
  • ENSP00000306102
  • ENSG00000197050
  • ENST00000337995
  • ENSP00000338770

Symbol
  • APAK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor
0.62
cell line
0.59
protein domain
0.58
transcription factor binding site profile
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.76   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.76   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
1
1
61.2
eosinophil percentage of leukocytes
1
1
1
35.2
platelet crit
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
61.2
eosinophil percentage of leukocytes
1
35.2
platelet crit
1
13.2
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 420
VGNC:11545
101059449
Macaque
zinc finger protein 420
713619
Mouse
MGI:2444666
233058
Rat
RGD:2323829
100359464
Dog
zinc finger protein 420
100682968
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 420
Macaque
zinc finger protein 420
Mouse
Rat
Dog
zinc finger protein 420
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TAQ5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Death Genes
Reactome
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Death Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Protein-Protein Interactions (16)
1 – 10 of 16
SAV1
Tbio
Novelty: 0.00962335
p_int: 0.999790755
p_ni: 0.000209245
Score: 0.747
Data Source: BioPlex,STRINGDB
RBM4
Tbio
Novelty: 0.02034191
p_int: 0.99948441
p_ni: 0.000021825
p_wrong: 0.000493765
Data Source: BioPlex
STK3
Tchem
Family: Kinase
Novelty: 0.0529257
p_int: 0.972185651
p_ni: 0.027814349
Score: 0.689
Data Source: BioPlex,STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.926331096
p_ni: 0.068348148
p_wrong: 0.005320756
Score: 0.197
Data Source: BioPlex,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.946
Data Source: STRINGDB
TRIM28
Tbio
Family: Epigenetic
Novelty: 0.00778381
Score: 0.939
Data Source: STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
Score: 0.921
Data Source: Reactome,STRINGDB
TP53AIP1
Tbio
Novelty: 0.03235108
Score: 0.918
Data Source: STRINGDB
POLE4
Tdark
Family: Enzyme
Novelty: 0.23346084
Score: 0.476
Data Source: STRINGDB
NFXL1
Tdark
Family: TF
Novelty: 0.1573945
Score: 0.469
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.76

PubMed score by year
PubTator Score  6.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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