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Tbio
MPLKIP
M-phase-specific PLK1-interacting protein

Protein Summary
Description
May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306984
  • ENSP00000304553
  • ENSG00000168303
  • ENST00000645701
  • ENSP00000495808

Symbol
  • C7orf11
  • TTDN1
  • ABHS
  • TTD4
  • ORF20
  • C7orf11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
histone modification site profile
0.77
tissue sample
0.56
tissue
0.53
cellular component
0.51


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.68   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.68   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
M-phase specific PLK1 interacting protein
VGNC:4431
736851
Macaque
M-phase specific PLK1 interacting protein
703092
Mouse
MGI:1913558
66308
Rat
RGD:1584365
684996
Dog
M-phase specific PLK1 interacting protein
VGNC:43339
100683984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
M-phase specific PLK1 interacting protein
Macaque
M-phase specific PLK1 interacting protein
Mouse
Rat
Dog
M-phase specific PLK1 interacting protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TAP9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (45)
1 – 10 of 45
DBR1
Tbio
Novelty:  0.02111317
p_int:  0.999861155
p_ni:  0.000138844
p_wrong:  2e-9
Score:  0.747
Data Source:  BioPlex,STRINGDB
NDOR1
Tbio
Family:  Enzyme
Novelty:  0.07400532
p_int:  0.977538664
p_ni:  0.000001741
p_wrong:  0.022459595
Data Source:  BioPlex
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
p_int:  0.928579119
p_ni:  0.071420881
Score:  0.183
Data Source:  BioPlex,STRINGDB
KCTD17
Tbio
Novelty:  0.12105733
p_int:  0.895231087
p_ni:  0.000039105
p_wrong:  0.104729808
Score:  0.187
Data Source:  BioPlex,STRINGDB
SUGCT
Tbio
Family:  Enzyme
Novelty:  0.0075902
Score:  0.906
Data Source:  STRINGDB
RBM27
Tdark
Novelty:  0.04875536
Score:  0.82
Data Source:  STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.82
Data Source:  STRINGDB
SUGP1
Tbio
Novelty:  0.00434166
Score:  0.818
Data Source:  STRINGDB
MRPL53
Tdark
Novelty:  1.0076471
Score:  0.794
Data Source:  STRINGDB
SCAMP3
Tbio
Novelty:  0.05504725
Score:  0.789
Data Source:  STRINGDB
Publication Statistics
PubMed Score  60.68

PubMed score by year
PubTator Score  12.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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