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Tbio
LMO3
LIM domain only protein 3

Protein Summary
Description
The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261169
  • ENSP00000261169
  • ENSG00000048540
  • ENST00000320122
  • ENSP00000312856
  • ENST00000354662
  • ENSP00000346689
  • ENST00000441439
  • ENSP00000412479
  • ENST00000447609
  • ENSP00000413703
  • ENST00000534946
  • ENSP00000439275
  • ENST00000535535
  • ENSP00000446115
  • ENST00000537304
  • ENSP00000440099
  • ENST00000540445
  • ENSP00000442786
  • ENST00000540848
  • ENSP00000445751
  • ENST00000541295
  • ENSP00000446463
  • ENST00000541846
  • ENSP00000444393

Symbol
  • RBTN3
  • RBTNL2
  • RHOM3
  • RBTN3
  • RHOM3
  • RBTNL2
  • Rhom-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.66
transcription factor
0.65
tissue sample
0.64
cell line
0.59
microRNA
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.72   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.72   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
91.8
self reported educational attainment
1
1
1
83
smoking cessation
1
1
1
77.5
mathematical ability
1
1
1
72.8
cigarettes per day measurement
1
1
1
69
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
91.8
self reported educational attainment
1
83
smoking cessation
1
77.5
mathematical ability
1
72.8
cigarettes per day measurement
1
69
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM domain only 3
VGNC:5455
465319
Mouse
MGI:102810
109593
Rat
RGD:1561357
497798
Dog
LIM domain only 3
VGNC:42723
486662
Horse
LIM domain only 3 [Source:HGNC Symbol;Acc:HGNC:6643]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM domain only 3
Mouse
Rat
Dog
LIM domain only 3
Horse
LIM domain only 3 [Source:HGNC Symbol;Acc:HGNC:6643]
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (45)
1 – 10 of 45
LMO1
Tbio
Novelty: 0.01670419
p_int: 0.999999997
p_wrong: 3e-9
Data Source: BioPlex
LDB2
Tbio
Novelty: 0.01621438
Score: 0.89
Data Source: STRINGDB
LDB1
Tbio
Novelty: 0.01110112
Score: 0.887
Data Source: STRINGDB
CSRP1
Tbio
Novelty: 0.01976527
Score: 0.764
Data Source: STRINGDB
CRIP1
Tbio
Novelty: 0.01263063
Score: 0.759
Data Source: STRINGDB
NR4A2
Tchem
Family: NR
Novelty: 0.00204712
Score: 0.64
Data Source: STRINGDB
TBR1
Tbio
Family: TF
Novelty: 0.00676736
Score: 0.623
Data Source: STRINGDB
NHLH2
Tbio
Family: TF
Novelty: 0.04744703
Score: 0.597
Data Source: STRINGDB
PAX6
Tbio
Family: TF
Novelty: 0.00064695
Score: 0.581
Data Source: STRINGDB
CSRP2
Tbio
Novelty: 0.04408353
Score: 0.566
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.72

PubMed score by year
PubTator Score  12.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer