Protein Summary
Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).
- ENST00000397283
- ENSP00000380453
- ENSG00000136541
- ENST00000410096
- ENSP00000387047
- KIAA1189
- JN
- KIAA1189
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.73 | ||
gene perturbation | 0.71 | ||
microRNA | 0.62 | ||
cellular component | 0.51 | ||
tissue | 0.46 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.97 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 93 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.97 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 93 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0