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Tbio
TTC8
Tetratricopeptide repeat protein 8

Protein Summary
Description
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. This gene encodes a protein that has been directly linked to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345383
  • ENSP00000339486
  • ENSG00000165533
  • ENST00000354441
  • ENSP00000346427
  • ENST00000380656
  • ENSP00000370031

Symbol
  • BBS8
  • BBS8
  • RP51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
cellular component
0.85
protein domain
0.85
cell line
0.66
cell type or tissue
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.98   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.98   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
5.8
age at onset
1
1
0
6.2
5.3
Myopia
1
1
0
6.2
5.3
refractive error measurement
1
1
0
6.2
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
5.8
age at onset
0
6.2
5.3
Myopia
0
6.2
5.3
refractive error measurement
0
6.2
5.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 8
VGNC:12404
467531
Macaque
tetratricopeptide repeat domain 8
694362
Mouse
MGI:1923510
76260
Rat
RGD:1307769
299246
Dog
tetratricopeptide repeat domain 8
VGNC:47963
480413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 8
Macaque
tetratricopeptide repeat domain 8
Mouse
Rat
Dog
tetratricopeptide repeat domain 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TAM2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
BBSome-mediated cargo-targeting to cilium (R-HSA-5620922)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
Protein-Protein Interactions (112)
1 – 10 of 112
BBS1
Tbio
Novelty:  0.00939439
p_int:  0.999999689
p_ni:  3.11e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
BBS5
Tbio
Novelty:  0.04208041
p_int:  0.999999463
p_ni:  5.17e-7
p_wrong:  2e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
LZTFL1
Tbio
Novelty:  0.10578428
p_int:  0.99992596
p_ni:  0.00007404
Score:  0.996
Data Source:  BioPlex,STRINGDB
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.999831299
p_ni:  0.000168701
Score:  0.994
Data Source:  BioPlex,STRINGDB
NME3
Tbio
Family:  Kinase
Novelty:  0.05947052
p_int:  0.999740155
p_ni:  0.000259728
p_wrong:  1.18e-7
Score:  0.829
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.998241051
p_ni:  0.001714602
p_wrong:  0.000044348
Score:  0.409
Data Source:  BioPlex,STRINGDB
BBS2
Tbio
Novelty:  0.00835161
Score:  0.987
Data Source:  STRINGDB
BBS9
Tbio
Novelty:  0.01879869
Score:  0.986
Data Source:  STRINGDB
BBS12
Tbio
Novelty:  0.06131428
Score:  0.98
Data Source:  STRINGDB
BBIP1
Tdark
Novelty:  0.23840637
Score:  0.978
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10.98

PubMed score by year
PubTator Score  14.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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