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Tbio
GABPB2
GA-binding protein subunit beta-2

Protein Summary
Description
May function as transcription factor capable of interacting with purine rich repeats (GA repeats).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368918
  • ENSP00000357914
  • ENSG00000143458

Symbol
  • GABPB-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
transcription factor
0.69
histone modification site profile
0.67
small molecule perturbation
0.66
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.34   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.34   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (77)
1 – 10 of 77
GABPA
Tbio
Family:  TF
Novelty:  0.01731451
p_int:  0.999999995
p_ni:  5e-9
Score:  0.911
Data Source:  BioPlex,STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.803
Data Source:  STRINGDB
BCL2L2
Tchem
Novelty:  0.00430896
Score:  0.799
Data Source:  STRINGDB
STMN4
Tbio
Novelty:  0.00422625
Score:  0.798
Data Source:  STRINGDB
CENPJ
Tbio
Novelty:  0.01337231
Score:  0.798
Data Source:  STRINGDB
KIF5B
Tbio
Novelty:  0.00515256
Score:  0.785
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.744
Data Source:  STRINGDB
MAPK10
Tchem
Family:  Kinase
Novelty:  0.00420573
Score:  0.744
Data Source:  STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.744
Data Source:  STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.74
Data Source:  STRINGDB
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
89.7
creatinine measurement
3
4
5
88.8
glomerular filtration rate
3
4
5
88.5
1
1
0
33.3
78.9
body mass index
3
3
3
77.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
89.7
creatinine measurement
5
88.8
glomerular filtration rate
5
88.5
0
33.3
78.9
body mass index
3
77.1
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GA binding protein transcription factor subunit beta 2
VGNC:8325
457284
Macaque
GA binding protein transcription factor beta subunit 2
716443
Mouse
MGI:95612
213054
Rat
RGD:1565234
295263
Dog
GA binding protein transcription factor subunit beta 2
VGNC:41052
475841
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GA binding protein transcription factor subunit beta 2
Macaque
GA binding protein transcription factor beta subunit 2
Mouse
Rat
Dog
GA binding protein transcription factor subunit beta 2
Publication Statistics
PubMed Score 1.34
PubMed score by year
PubTator Score 0.92
PubTator score by year