Tbio RHEBL1 GTPase RhebL1

Protein Summary

Description

Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.

Uniprot Accession IDs

• Q8TAI7
• Q56VH8

Gene Name

• RHEBL1

Ensembl ID

• ENST00000301068
• ENSP00000301068
• ENSG00000167550
• ENST00000550797
• ENSP00000446726

Symbol

• RHEBL1c

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
virus perturbation	0.85
molecular function	0.81
transcription factor	0.75
transcription factor binding site profile	0.75

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtpase Rhebl1

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtpase Rhebl1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.6   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.6   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0