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Tbio
EXOC6
Exocyst complex component 6

Protein Summary
Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260762
  • ENSP00000260762
  • ENSG00000138190
  • ENST00000371552
  • ENSP00000360607

Symbol
  • SEC15A
  • SEC15L
  • SEC15L1
  • SEC15
  • EXOC6A
  • SEC15L
  • Sec15p
  • SEC15L1
  • SEC15L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.91
transcription factor perturbation
0.88
virus perturbation
0.72
kinase perturbation
0.71
cell type or tissue
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.93   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.93   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
91.6
1
2
0
1.3
76.7
intraocular pressure measurement
2
1
2
74
age-related hearing impairment
1
1
0
5.5
51.6
eosinophil percentage of leukocytes
1
1
1
29.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
91.6
0
1.3
76.7
intraocular pressure measurement
2
74
age-related hearing impairment
0
5.5
51.6
eosinophil percentage of leukocytes
1
29.6
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exocyst complex component 6
VGNC:3844
450613
Macaque
exocyst complex component 6
700046
Mouse
MGI:1351611
107371
Rat
RGD:3653
50556
Dog
exocyst complex component 6
VGNC:40516
477771
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exocyst complex component 6
Macaque
exocyst complex component 6
Mouse
Rat
Dog
exocyst complex component 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TAG9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (41)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Insulin processing
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Insulin processing
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (11)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (150)
1 – 10 of 150
EXOC3
Tbio
Novelty: 0.01051955
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOC8
Tbio
Novelty: 0.03090842
p_int: 0.999999999
p_ni: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOC1
Tbio
Novelty: 0.01073858
p_int: 0.999999993
p_ni: 7e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
EXOC7
Tbio
Novelty: 0.00852508
p_int: 0.999999733
p_ni: 2.67e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOC5
Tbio
Novelty: 0.02200205
p_int: 0.999999207
p_ni: 7.93e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
IL1R2
Tbio
Novelty: 0.00820359
p_int: 0.999994882
p_ni: 0.000005116
p_wrong: 1e-9
Score: 0.594
Data Source: BioPlex,STRINGDB
EXOC2
Tbio
Novelty: 0.01434464
p_int: 0.999921363
p_ni: 0.00007863
p_wrong: 7e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
CARD19
Tbio
Family: Enzyme
Novelty: 0.18215136
p_int: 0.999802788
p_ni: 0.000195363
p_wrong: 0.00000185
Score: 0.173
Data Source: BioPlex,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
p_int: 0.999717595
p_ni: 0.000277223
p_wrong: 0.000005182
Score: 0.5
Data Source: BioPlex,STRINGDB
SEMA4C
Tbio
Novelty: 0.01237067
p_int: 0.99965299
p_ni: 0.00034701
Data Source: BioPlex
Publication Statistics
PubMed Score  50.93

PubMed score by year
PubTator Score  16.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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