Tbio EXOC6 Exocyst complex component 6

Protein Summary

Description

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q8TAG9
• E9PHI3
• Q5VXH8
• Q9NZ24

Gene Name

• EXOC6

Ensembl ID

• ENST00000260762
• ENSP00000260762
• ENSG00000138190
• ENST00000371552
• ENSP00000360607

Symbol

• SEC15A
• SEC15L
• SEC15L1
• SEC15
• EXOC6A
• SEC15L
• Sec15p
• SEC15L1
• SEC15L3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.91
transcription factor perturbation	0.88
virus perturbation	0.72
kinase perturbation	0.71
cell type or tissue	0.69

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Exocyst Complex Component 6

DTO Classes

Protein / Transporter / Exocyst Complex Component 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.25   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.25   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0