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Tbio
WDR48
WD repeat-containing protein 48

Protein Summary
Description
Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27650958, PubMed:27373336). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27650958, PubMed:27373336). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302313
  • ENSP00000307491
  • ENSG00000114742

Symbol
  • KIAA1449
  • UAF1
  • P80
  • UAF1
  • SPG60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.87
protein domain
0.85
interacting protein
0.78
transcription factor binding site profile
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.97   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.97   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (157)
USP46
Tbio
Family:  Enzyme
Novelty:  0.04594593
p_int:  0.999747605
p_ni:  0.000252395
Score:  0.999
Data Source:  BioPlex,STRINGDB
RAD51AP1
Tbio
Novelty:  0.04859066
p_int:  0.999544402
p_ni:  0.000455598
Score:  0.939
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.993016249
p_ni:  0.006983751
Score:  0.158
Data Source:  BioPlex,STRINGDB
WDR20
Tbio
Novelty:  0.03031804
p_int:  0.987235257
p_ni:  0.012764743
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.97424126
p_ni:  0.02575874
Score:  0.552
Data Source:  BioPlex,STRINGDB
USP1
Tchem
Family:  Enzyme
Novelty:  0.0092606
p_int:  0.959785846
p_ni:  0.040214154
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
p_int:  0.777855818
p_ni:  0.222144182
Score:  0.686
Data Source:  BioPlex,STRINGDB
USP12
Tbio
Family:  Enzyme
Novelty:  0.0460009
Score:  0.999
Data Source:  Reactome,STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.997
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Fanconi Anemia Pathway
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Repair
Deubiquitination
Fanconi Anemia Pathway
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
60.5
platelet crit
1
1
1
57.8
platelet count
1
1
1
54.4
metabolic syndrome
1
1
1
15.8
apolipoprotein A 1 measurement
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
60.5
platelet crit
1
57.8
platelet count
1
54.4
metabolic syndrome
1
15.8
apolipoprotein A 1 measurement
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 48
VGNC:2629
460277
Macaque
WD repeat domain 48
695026
Mouse
MGI:1914811
67561
Rat
RGD:1309702
363164
Dog
WD repeat domain 48
VGNC:48371
477027
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 48
Macaque
WD repeat domain 48
Mouse
Rat
Dog
WD repeat domain 48
Publication Statistics
PubMed Score 29.97
PubMed score by year
PubTator Score 17.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title