GADD45GIP1
Growth arrest and DNA damage-inducible proteins-interacting protein 1
Protein Summary
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]
- ENST00000316939
- ENSP00000323065
- ENSG00000179271
- MRPL59
- PLINP1
- PRG6
- PRG6
- CRIF1
- PLINP
- CKBBP2
- Plinp1
- MRP-L59
- PLINP-1
- CKbetaBP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.87 | ||
cell type or tissue | 0.8 | ||
transcription factor perturbation | 0.74 | ||
virus | 0.66 | ||
tissue sample | 0.61 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.41 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 144 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.41 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 144 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | GADD45G interacting protein 1 | VGNC:3634 | 747626 | |||||
Mouse | MGI:1914947 | 102060 | ||||||
Rat | RGD:1309249 | 288916 | ||||||
Dog | GADD45G interacting protein 1 | VGNC:41072 | 476693 | |||||
Cow | GADD45G interacting protein 1 | VGNC:29209 | 504718 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | GADD45G interacting protein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | GADD45G interacting protein 1 | |||||
Cow | GADD45G interacting protein 1 | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Mitochondrial translation | ||||
Reactome | Mitochondrial translation elongation | ||||
Reactome | Mitochondrial translation initiation | ||||
Reactome | Mitochondrial translation termination | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Mitochondrial translation | ||||
Mitochondrial translation elongation | ||||
Mitochondrial translation initiation | ||||
Mitochondrial translation termination | ||||
Gene Ontology Terms (8)
Components (4)
Processes (4)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (156)
1 – 10 of 156
RPL37
Novelty: 0.03935854
p_int: 0.99994705
p_ni: 0.00005295
Data Source: BioPlex
MRPL18
Novelty: 0.73438796
p_int: 0.999913486
p_ni: 0.000086514
Score: 0.99
Data Source: BioPlex,STRINGDB
MRPL47
Novelty: 0.05648009
p_int: 0.999909005
p_ni: 0.000090995
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL30
Novelty: 1.03623556
p_int: 0.999563482
p_ni: 0.000436518
Score: 0.982
Data Source: BioPlex,STRINGDB
EDC3
Novelty: 0.02077346
p_int: 0.999524084
p_ni: 0.000475916
Data Source: BioPlex
MRPL50
Novelty: 0.88879319
p_int: 0.999412095
p_ni: 0.000587905
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL53
Novelty: 1.0076471
p_int: 0.999158383
p_ni: 0.000841617
Score: 0.984
Data Source: BioPlex,STRINGDB
HECTD3
Family: Enzyme
Novelty: 2.20874654
p_int: 0.998788694
p_ni: 0.001211306
Data Source: BioPlex
MRPL4
Novelty: 0.27290276
p_int: 0.998724051
p_ni: 0.001275949
Score: 0.994
Data Source: BioPlex,STRINGDB
MRPL42
Novelty: 0.48241447
p_int: 0.998707342
p_ni: 0.001292658
Score: 0.994
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 37.41
PubMed score by year
PubTator Score 14.21
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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