Tbio GADD45GIP1 Growth arrest and DNA damage-inducible proteins-interacting protein 1

Protein Summary

Description

Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q8TAE8
• Q8IVM3
• Q8TE51
• Q969P9
• Q9BSM6

Gene Name

• GADD45GIP1

Ensembl ID

• ENST00000316939
• ENSP00000323065
• ENSG00000179271

Symbol

• MRPL59
• PLINP1
• PRG6
• PRG6
• CRIF1
• PLINP
• CKBBP2
• Plinp1
• MRP-L59
• PLINP-1
• CKbetaBP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.87
cell type or tissue	0.8
transcription factor perturbation	0.74
virus	0.66
tissue sample	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.73   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 144   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.73   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (156)

Explore Interacting Targets

1 – 10 of 156

• See Interactions on String-DB

RPL37

Tbio

Novelty:  0.03935854

p_int:  0.99994705

p_ni:  0.00005295

Data Source:  BioPlex

MRPL18

Tbio

Novelty:  0.73438796

p_int:  0.999913486

p_ni:  0.000086514

Score:  0.99

Data Source:  BioPlex,STRINGDB

MRPL47

Tbio

Novelty:  0.05648009

p_int:  0.999909005

p_ni:  0.000090995

Score:  0.996

Data Source:  BioPlex,STRINGDB

MRPL30

Tdark

Novelty:  1.03623556

p_int:  0.999563482

p_ni:  0.000436518

Score:  0.982

Data Source:  BioPlex,STRINGDB

EDC3

Tbio

Novelty:  0.02077346

p_int:  0.999524084

p_ni:  0.000475916

Data Source:  BioPlex

MRPL50

Tdark

Novelty:  0.88879319

p_int:  0.999412095

p_ni:  0.000587905

Score:  0.996

Data Source:  BioPlex,STRINGDB

MRPL53

Tdark

Novelty:  1.0076471

p_int:  0.999158383

p_ni:  0.000841617

Score:  0.984

Data Source:  BioPlex,STRINGDB

HECTD3

Tdark

Family:  Enzyme

Novelty:  2.20874654

p_int:  0.998788694

p_ni:  0.001211306

Data Source:  BioPlex

MRPL4

Tdark

Novelty:  0.27290276

p_int:  0.998724051

p_ni:  0.001275949

Score:  0.994

Data Source:  BioPlex,STRINGDB

MRPL42

Tbio

Novelty:  0.48241447

p_int:  0.998707342

p_ni:  0.001292658

Score:  0.994

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (6)

Metabolism of proteins (R-HSA-392499)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Mitochondrial translation	96 targets	R-HSA-5368287
Reactome	Mitochondrial translation elongation	90 targets	R-HSA-5389840
Reactome	Mitochondrial translation initiation	90 targets	R-HSA-5368286
Reactome	Mitochondrial translation termination	90 targets	R-HSA-5419276

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Mitochondrial translation	96 targets	R-HSA-5368287
Mitochondrial translation elongation	90 targets	R-HSA-5389840
Mitochondrial translation initiation	90 targets	R-HSA-5368286
Mitochondrial translation termination	90 targets	R-HSA-5419276

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Components (4)

Processes (4)

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1 – 4 of 4

GO Term	Evidence	Assigned by
mitochondrion	Inferred from Direct Assay (IDA)	HPA
mitochondrial matrix	Traceable Author Statement (TAS)	Reactome
nucleus	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
ribosome	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (33)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 33

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	3	6	6		98.2
reticulocyte measurement	EFO_0010700	3	4	5		97.2
mean corpuscular hemoglobin concentration	EFO_0004528	3	3	3		97
erythrocyte count	EFO_0004305	3	5	5		96.7
reticulocyte count	EFO_0007986	7	4	8		96.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 33

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	6		98.2
reticulocyte measurement	EFO_0010700	5		97.2
mean corpuscular hemoglobin concentration	EFO_0004528	3		97
erythrocyte count	EFO_0004305	5		96.7
reticulocyte count	EFO_0007986	8		96.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell cycle
Coiled coil
Complete proteome
Host-virus interaction
Mitochondrion
Nucleus
Reference proteome
Ribonucleoprotein
Ribosomal protein

GWAS Trait Find Similar Targets

No Header	No Header
bipolar disorder
blood metabolite measurement
BMI-adjusted waist-hip ratio
body mass index
cognitive function measurement
cortical surface area measurement
Drugs used in diabetes use measurement
erythrocyte count
erythrocyte measurement
glomerular filtration rate

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	GADD45G interacting protein 1	VGNC:3634	747626
Mouse	growth arrest and DNA-damage-inducible, gamma interacting protein 1	MGI:1914947	102060
Rat	GADD45G interacting protein 1	RGD:1309249	288916
Dog	GADD45G interacting protein 1	VGNC:41072	476693
Cow	GADD45G interacting protein 1	VGNC:29209	504718

Species	Name	OMA	EggNOG	Inparanoid
Chimp	GADD45G interacting protein 1
Mouse	growth arrest and DNA-damage-inducible, gamma interacting protein 1
Rat	GADD45G interacting protein 1
Dog	GADD45G interacting protein 1
Cow	GADD45G interacting protein 1

Publication Statistics

PubMed Score 38.73

PubMed score by year

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PubTator Score 14.21

PubTator score by year

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Related Publications

Text Mined References (30)

GeneRif Annotations (17)

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PMID	Year	Title