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Tclin
KCNG3
Potassium voltage-gated channel subfamily G member 3

Protein Summary
Description
Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306078
  • ENSP00000304127
  • ENSG00000171126
  • ENST00000394973
  • ENSP00000378424

Symbol
  • KV6.3
  • KV10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.84
molecular function
0.84
transcription factor binding site profile
0.72
microRNA
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.931
Data Source:  STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.923
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.917
Data Source:  STRINGDB
P62861
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
KBTBD12
Tdark
Novelty:  3.42794501
Score:  0.743
Data Source:  STRINGDB
KLHDC8B
Tbio
Novelty:  0.15409379
Score:  0.733
Data Source:  STRINGDB
KCTD2
Tdark
Novelty:  0.42992811
Score:  0.73
Data Source:  STRINGDB
CCDC36
Tbio
Novelty:  0.17724141
Score:  0.709
Data Source:  STRINGDB
TMEM204
Tdark
Novelty:  0.21947862
Score:  0.706
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
1
2
0
1.1
55.8
IGF-1 measurement
1
1
1
44.2
high density lipoprotein cholesterol measurement
1
1
1
35
mathematical ability
1
1
1
24.5
BMI-adjusted hip circumference
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1.1
55.8
IGF-1 measurement
1
44.2
high density lipoprotein cholesterol measurement
1
35
mathematical ability
1
24.5
BMI-adjusted hip circumference
1
21.5
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel modifier subfamily G member 3
VGNC:7697
470361
Mouse
MGI:2663923
225030
Rat
RGD:628832
171011
Dog
potassium voltage-gated channel modifier subfamily G member 3
VGNC:42246
483049
Cow
potassium voltage-gated channel modifier subfamily G member 3 [Source:HGNC Symbol;Acc:HGNC:18306]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel modifier subfamily G member 3
Mouse
Rat
Dog
potassium voltage-gated channel modifier subfamily G member 3
Cow
potassium voltage-gated channel modifier subfamily G member 3 [Source:HGNC Symbol;Acc:HGNC:18306]
Publication Statistics
PubMed Score 4.09
PubMed score by year
PubTator Score 20.95
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title