KCNG3
Potassium voltage-gated channel subfamily G member 3
Protein Summary
Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
- ENST00000306078
- ENSP00000304127
- ENSG00000171126
- ENST00000394973
- ENSP00000378424
- KV6.3
- KV10.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
histone modification site profile | 0.84 | ||
molecular function | 0.84 | ||
transcription factor binding site profile | 0.72 | ||
microRNA | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.09 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 138 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.09 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 138 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (0)
Protein-Protein Interactions (138)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Neuronal System | ||||
Reactome | Potassium Channels | ||||
Reactome | Voltage gated Potassium channels | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Neuronal System | ||||
Potassium Channels | ||||
Voltage gated Potassium channels | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
insomnia measurement | 1 | 2 | 0 | 1.1 | 55.8 | ||||
IGF-1 measurement | 1 | 1 | 1 | 44.2 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 35 | |||||
mathematical ability | 1 | 1 | 1 | 24.5 | |||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
insomnia measurement | 0 | 1.1 | 55.8 | ||||
IGF-1 measurement | 1 | 44.2 | |||||
high density lipoprotein cholesterol measurement | 1 | 35 | |||||
mathematical ability | 1 | 24.5 | |||||
BMI-adjusted hip circumference | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Reagents (1)
Mouse
IDG-KCNG3-TRAP-MOUSE
Details:
- Allele: Kcng3tm1e(KOMP)Wtsi
Data:
- IDG-KCNG3-TRAP-MOUSE
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | potassium voltage-gated channel modifier subfamily G member 3 | VGNC:7697 | 470361 | |||||
Mouse | MGI:2663923 | 225030 | ||||||
Rat | RGD:628832 | 171011 | ||||||
Dog | potassium voltage-gated channel modifier subfamily G member 3 | VGNC:42246 | 483049 | |||||
Cow | potassium voltage-gated channel modifier subfamily G member 3 [Source:HGNC Symbol;Acc:HGNC:18306] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | potassium voltage-gated channel modifier subfamily G member 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | potassium voltage-gated channel modifier subfamily G member 3 | |||||
Cow | potassium voltage-gated channel modifier subfamily G member 3 [Source:HGNC Symbol;Acc:HGNC:18306] | |||||
Publication Statistics
PubMed Score 4.09
PubMed score by year
PubTator Score 20.95
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (11)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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