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Tclin
KCNG3
Potassium voltage-gated channel subfamily G member 3

Protein Summary
Description
Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306078
  • ENSP00000304127
  • ENSG00000171126
  • ENST00000394973
  • ENSP00000378424

Symbol
  • KV6.3
  • KV10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.84
molecular function
0.84
transcription factor binding site profile
0.72
microRNA
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
54.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
54.7
Pathways (3)
Neuronal System (R-HSA-112316)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Protein-Protein Interactions (138)
1 – 10 of 138
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.931
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.923
Data Source: STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.917
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
KBTBD12
Tdark
Novelty: 3.42794501
Score: 0.743
Data Source: STRINGDB
KLHDC8B
Tbio
Novelty: 0.15409379
Score: 0.733
Data Source: STRINGDB
KCTD2
Tdark
Novelty: 0.42992811
Score: 0.73
Data Source: STRINGDB
CCDC36
Tbio
Novelty: 0.17724141
Score: 0.709
Data Source: STRINGDB
TMEM204
Tdark
Novelty: 0.21947862
Score: 0.706
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.09

PubMed score by year
PubTator Score  20.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer