Tclin KCNG3 Potassium voltage-gated channel subfamily G member 3

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / G Subfamily / Kv6.3/kcng3 Sub-subfamily / Potassium Voltage-gated Channel Subfamily G Member 3

Protein Summary

Description

Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TAE7
• Q53SC1

Gene Name

• KCNG3

Ensembl ID

• ENST00000306078
• ENSP00000304127
• ENSG00000171126
• ENST00000394973
• ENSP00000378424

Symbol

• KV6.3
• KV10.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
histone modification site profile	0.84
molecular function	0.84
transcription factor binding site profile	0.72
microRNA	0.67

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3

Approved Drugs (3)

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1 – 3 of 3

fampridine

KCNG3Tclin IC

BLOCKER :

guanidine

KCNG3Tclin IC

BLOCKER :

amifampridine

KCNG3Tclin IC

BLOCKER :

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1	1	1		54.7

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1		54.7

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Pathways (3)

Reactome (3)

Neuronal System (R-HSA-112316)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Neuronal System	398 targets	R-HSA-112316
Reactome	Potassium Channels	99 targets	R-HSA-1296071
Reactome	Voltage gated Potassium channels	43 targets	R-HSA-1296072

Name	Explore in Pharos	Explore in Source
Neuronal System	398 targets	R-HSA-112316
Potassium Channels	99 targets	R-HSA-1296071
Voltage gated Potassium channels	43 targets	R-HSA-1296072

Gene Ontology Terms (9)

Functions (2)

Components (4)

Processes (3)

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GO Term	Evidence	Assigned by
delayed rectifier potassium channel activity	Inferred from Direct Assay (IDA)	UniProtKB
voltage-gated potassium channel activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (138)

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1 – 10 of 138

• See Interactions on String-DB

KCNAB1

Tbio

Family: IC

Novelty: 0.01413705

Score: 0.931

Data Source: STRINGDB

KCNAB3

Tbio

Family: IC

Novelty: 0.10128237

Score: 0.923

Data Source: STRINGDB

KCNAB2

Tbio

Family: IC

Novelty: 0.01752175

Score: 0.917

Data Source: STRINGDB

FAU

Tbio

Novelty: 0.01170009

Score: 0.788

Data Source: STRINGDB

FAU

Tbio

Novelty: 0.01170009

Score: 0.788

Data Source: STRINGDB

KBTBD12

Tdark

Novelty: 3.42794501

Score: 0.743

Data Source: STRINGDB

KLHDC8B

Tbio

Novelty: 0.15409379

Score: 0.733

Data Source: STRINGDB

KCTD2

Tdark

Novelty: 0.42992811

Score: 0.73

Data Source: STRINGDB

CCDC36

Tbio

Novelty: 0.17724141

Score: 0.709

Data Source: STRINGDB

TMEM204

Tdark

Novelty: 0.21947862

Score: 0.706

Data Source: STRINGDB

Publication Statistics

PubMed Score  4.09

PubMed score by year

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PubTator Score  20.95

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Ion channel
Ion transport
Membrane
Potassium
Potassium channel
Potassium transport

GWAS Trait Find Similar Targets

mathematical ability