Tclin KCNG3 Potassium voltage-gated channel subfamily G member 3

Protein Summary

Description

Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TAE7
• Q53SC1

Gene Name

• KCNG3

Ensembl ID

• ENST00000306078
• ENSP00000304127
• ENSG00000171126
• ENST00000394973
• ENSP00000378424

Symbol

• KV6.3
• KV10.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
histone modification site profile	0.84
molecular function	0.84
transcription factor binding site profile	0.72
microRNA	0.67

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / G Subfamily / Kv6.3/kcng3 Sub-subfamily / Potassium Voltage-gated Channel Subfamily G Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.42   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.42   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3