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Tbio
SNIP1
Smad nuclear-interacting protein 1

Protein Summary
Description
Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296215
  • ENSP00000296215
  • ENSG00000163877

Symbol
  • PML1
  • PMRED
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
kinase perturbation
0.71
hub protein
0.67
transcription factor binding site profile
0.67
microRNA
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.92   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.92   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (221)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
TGF-beta signaling pathway
PathwayCommons: pid
Regulation of nuclear SMAD2/3 signaling
PathwayCommons: netpath
TGF_beta_Receptor
Name
Explore in Pharos
Explore in Source
TGF-beta signaling pathway
Regulation of nuclear SMAD2/3 signaling
TGF_beta_Receptor
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (140)
1 – 10 of 140
TMEM184B
Tdark
Novelty: 0.35340207
p_int: 0.999999996
p_ni: 1e-9
p_wrong: 3e-9
Score: 0.519
Data Source: BioPlex,STRINGDB
WSB2
Tbio
Novelty: 0.03939755
p_int: 0.999999993
p_ni: 4e-9
p_wrong: 3e-9
Score: 0.746
Data Source: BioPlex,STRINGDB
CLASRP
Tbio
Novelty: 0.00582947
p_int: 0.999999444
p_ni: 5.56e-7
Score: 0.192
Data Source: BioPlex,STRINGDB
ACIN1
Tbio
Novelty: 0.01675479
p_int: 0.999995323
p_ni: 0.000004677
Score: 0.412
Data Source: BioPlex,STRINGDB
RNPS1
Tbio
Novelty: 0.03203224
p_int: 0.99993574
p_ni: 0.00006426
Score: 0.304
Data Source: BioPlex,STRINGDB
PNN
Tbio
Novelty: 0.01395394
p_int: 0.999889849
p_ni: 0.000110151
Score: 0.678
Data Source: BioPlex,STRINGDB
CCDC9
Tdark
Novelty: 0.73149492
p_int: 0.999878075
p_ni: 0.00012192
p_wrong: 6e-9
Score: 0.505
Data Source: BioPlex,STRINGDB
SRSF8
Tdark
Novelty: 0.16509556
p_int: 0.999779191
p_ni: 0.000220807
p_wrong: 2e-9
Score: 0.498
Data Source: BioPlex,STRINGDB
NKTR
Tbio
Novelty: 0.01287691
p_int: 0.999742
p_ni: 0.000257999
p_wrong: 1e-9
Score: 0.478
Data Source: BioPlex,STRINGDB
ZC3H14
Tbio
Novelty: 0.07532778
p_int: 0.999637461
p_ni: 0.000362539
Score: 0.37
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  52.92

PubMed score by year
PubTator Score  14.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer