Tbio SLC30A5 Zinc transporter 5

Protein Summary

Description

Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP. This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q8TAD4
• B7ZM89
• Q6UX54
• Q7L4M4
• Q8TDG3
• Q9BVY8
• Q9H9H1
• ZnT-5

Gene Name

• SLC30A5

Ensembl ID

• ENST00000380860
• ENSP00000370241
• ENSG00000145740
• ENST00000396591
• ENSP00000379836
• ENST00000502979
• ENSP00000421251

Symbol

• ZNT5
• ZNTL1
• ZTL1
• ZNT5
• ZTL1
• ZNTL1
• ZnT-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.89
cellular component	0.88
transcription factor perturbation	0.74
kinase perturbation	0.71
transcription factor	0.71

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc30 Zinc Transporter Family / Zinc Transporter 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.83   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 45   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.83   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0