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Tbio
SLC30A5
Zinc transporter 5

Protein Summary
Description
Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP. This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosom ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380860
  • ENSP00000370241
  • ENSG00000145740
  • ENST00000396591
  • ENSP00000379836
  • ENST00000502979
  • ENSP00000421251

Symbol
  • ZNT5
  • ZNTL1
  • ZTL1
  • ZNT5
  • ZTL1
  • ZNTL1
  • ZnT-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
cellular component
0.88
transcription factor perturbation
0.74
kinase perturbation
0.71
transcription factor
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.83   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.83   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.999995648
p_ni:  0.000004352
Data Source:  BioPlex
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.999746743
p_ni:  0.000253245
p_wrong:  1.2e-8
Data Source:  BioPlex
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.998917023
p_ni:  0.001082977
Data Source:  BioPlex
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.998437959
p_ni:  0.001375553
p_wrong:  0.000186488
Score:  0.267
Data Source:  BioPlex,STRINGDB
CYB5D2
Tbio
Novelty:  0.23122479
p_int:  0.998342858
p_ni:  0.001657136
p_wrong:  6e-9
Data Source:  BioPlex
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.998121542
p_ni:  0.001877843
p_wrong:  6.15e-7
Score:  0.387
Data Source:  BioPlex,STRINGDB
TPRA1
Tbio
Family:  GPCR
Novelty:  0.16743826
p_int:  0.99764734
p_ni:  0.002351815
p_wrong:  8.45e-7
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.997360459
p_ni:  0.002639472
p_wrong:  6.8e-8
Score:  0.17
Data Source:  BioPlex,STRINGDB
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.996833753
p_ni:  0.003002251
p_wrong:  0.000163996
Data Source:  BioPlex
CLPSL1
Tdark
Family:  Enzyme
Novelty:  0.32091586
p_int:  0.989853136
p_ni:  0.01014582
p_wrong:  0.000001044
Score:  0.167
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Insulin processing (R-HSA-264876)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin processing
Reactome
Metabolism of proteins
Reactome
Metal ion SLC transporters
Reactome
Peptide hormone metabolism
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Insulin processing
Metabolism of proteins
Metal ion SLC transporters
Peptide hormone metabolism
SLC-mediated transmembrane transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
51.6
total blood protein measurement
1
1
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
51.6
total blood protein measurement
1
2.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 5
VGNC:8642
101059378
Macaque
solute carrier family 30 member 5
699371
Mouse
MGI:1916298
69048
Rat
RGD:1306931
294698
Dog
solute carrier family 30 member 5
VGNC:46350
487237
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 5
Macaque
solute carrier family 30 member 5
Mouse
Rat
Dog
solute carrier family 30 member 5
Publication Statistics
PubMed Score 43.83
PubMed score by year
PubTator Score 17.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title