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Tbio
IL17D
Interleukin-17D

Protein Summary
Description
Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells. The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304920
  • ENSP00000302924
  • ENSG00000172458

Symbol
  • IL-17D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
histone modification site profile
0.78
cell type or tissue
0.67
transcription factor binding site profile
0.55
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.62   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.62   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
5
5.8
PR segment
1
1
0
1.6
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
5
5.8
PR segment
0
1.6
3.7
Pathways (31)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
JAK-STAT signaling pathway
KEGG
C-type lectin receptor signaling pathway
KEGG
Th17 cell differentiation
KEGG
IL-17 signaling pathway
KEGG
Cytokine-cytokine receptor interaction
Name
Explore in Pharos
Explore in Source
JAK-STAT signaling pathway
C-type lectin receptor signaling pathway
Th17 cell differentiation
IL-17 signaling pathway
Cytokine-cytokine receptor interaction
Protein-Protein Interactions (65)
1 – 10 of 65
IL25
Tbio
Novelty: 0.01620324
Score: 0.862
Data Source: STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.821
Data Source: STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.821
Data Source: STRINGDB
IL27RA
Tbio
Novelty: 0.01348051
Score: 0.82
Data Source: STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.813
Data Source: STRINGDB
IL20RA
Tbio
Novelty: 0.02416816
Score: 0.78
Data Source: STRINGDB
IL17RE
Tbio
Novelty: 0.07568341
Score: 0.766
Data Source: STRINGDB
IL17RB
Tbio
Novelty: 0.01540031
Score: 0.765
Data Source: STRINGDB
IL23R
Tbio
Novelty: 0.00434717
Score: 0.76
Data Source: STRINGDB
IL17RC
Tclin
Novelty: 0.01844832
Score: 0.752
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.62

PubMed score by year
PubTator Score  11.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer