You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
JOSD2
Josephin-2

Protein Summary
Description
Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme. This gene encodes a protein containing a Josephin domain. Josephin domain-containing proteins are deubiquitinating enzymes which catalyze the hydrolysis of the bond between the C-terminal glycine of the ubiquitin peptide and protein substrates. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000595669
  • ENSP00000468860
  • ENSG00000161677
  • ENST00000598418
  • ENSP00000468956
  • ENST00000601423
  • ENSP00000472116

Symbol
  • SBBI54
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
gene perturbation
0.76
transcription factor binding site profile
0.73
transcription factor
0.72
cell type or tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.9   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.9   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
73
2
1
0
1.4
58.4
electrocardiography
1
1
1
14.2
hematocrit
1
1
1
12.9
hemoglobin measurement
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
73
0
1.4
58.4
electrocardiography
1
14.2
hematocrit
1
12.9
hemoglobin measurement
1
11.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Josephin domain containing 2
106992294
Mouse
MGI:1913374
66124
Dog
Josephin domain containing 2
VGNC:42193
611845
Pig
Josephin domain containing 2
100627842
Anole lizard
Josephin domain containing 2
100557699
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Josephin domain containing 2
Mouse
Dog
Josephin domain containing 2
Pig
Josephin domain containing 2
Anole lizard
Josephin domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TAC2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Josephin domain DUBs
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Deubiquitination
Josephin domain DUBs
Metabolism of proteins
Post-translational protein modification
Protein-Protein Interactions (63)
1 – 10 of 63
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.999992459
p_ni:  0.000007541
Data Source:  BioPlex
TRAPPC2
Tbio
Novelty:  0.02016231
p_int:  0.999948428
p_ni:  0.000051572
Score:  0.169
Data Source:  BioPlex,STRINGDB
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.99985759
p_ni:  0.00014241
Score:  0.243
Data Source:  BioPlex,STRINGDB
MCEMP1
Tdark
Novelty:  0.14180782
p_int:  0.995608763
p_ni:  0.004391237
Score:  0.513
Data Source:  BioPlex,STRINGDB
TYSND1
Tbio
Family:  Enzyme
Novelty:  0.16036122
p_int:  0.99436847
p_ni:  0.005631394
p_wrong:  1.36e-7
Score:  0.513
Data Source:  BioPlex,STRINGDB
HBB
Tbio
Novelty:  0.00049683
p_int:  0.984265398
p_ni:  0.015620443
p_wrong:  0.00011416
Data Source:  BioPlex
SPRR3
Tbio
Novelty:  0.0241484
p_int:  0.98150845
p_ni:  0.018483847
p_wrong:  0.000007703
Score:  0.196
Data Source:  BioPlex,STRINGDB
NDUFA8
Tclin
Family:  Enzyme
Novelty:  0.05772867
p_int:  0.949075976
p_ni:  0.05092358
p_wrong:  4.44e-7
Score:  0.154
Data Source:  BioPlex,STRINGDB
DUSP28
Tbio
Family:  Enzyme
Novelty:  0.0339081
p_int:  0.918887674
p_ni:  0.000340658
p_wrong:  0.080771668
Score:  0.297
Data Source:  BioPlex,STRINGDB
LRTOMT
Tbio
Novelty:  0.04036751
p_int:  0.851366859
p_ni:  0.148632947
p_wrong:  1.94e-7
Score:  0.382
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.90

PubMed score by year
PubTator Score  0.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer