Tbio GRPEL2 GrpE protein homolog 2, mitochondrial

Protein Summary

Description

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).

Uniprot Accession IDs

• Q8TAA5
• B4DFA6
• Q49AJ6

Gene Name

• GRPEL2

Ensembl ID

• ENST00000329271
• ENSP00000329558
• ENSG00000164284
• ENST00000416916
• ENSP00000397302

Symbol

• Mt-GrpE#2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.82
kinase perturbation	0.81
cell type or tissue	0.78
microRNA	0.77
histone modification site profile	0.76

Protein Classes

PANTHER Classes

Protein / Chaperone / Grpe Protein Homolog 2, Mitochondrial

DTO Classes

Protein / Chaperone / Grpe Protein Homolog 2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.51   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.51   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0