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Tbio
COQ8A
Atypical kinase COQ8A, mitochondrial

Protein Summary
Description
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144). This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366777
  • ENSP00000355739
  • ENSG00000163050
  • ENST00000366778
  • ENSP00000355740
  • ENST00000366779
  • ENSP00000355741

Symbol
  • ADCK3
  • CABC1
  • COQ8
  • ADCK3
  • ARCA2
  • CABC1
  • SCAR9
  • COQ10D4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.99   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.99   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
92.7
myeloid white cell count
2
2
2
85
neutrophil percentage of leukocytes
2
2
2
80.6
lymphocyte percentage of leukocytes
2
2
2
80.3
BMI-adjusted waist circumference
1
3
3
73.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
92.7
myeloid white cell count
2
85
neutrophil percentage of leukocytes
2
80.6
lymphocyte percentage of leukocytes
2
80.3
BMI-adjusted waist circumference
3
73.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coenzyme Q8A
VGNC:28
457791
Macaque
coenzyme Q8A
697920
Mouse
MGI:1914676
67426
Rat
RGD:1308245
360887
Dog
coenzyme Q8A
VGNC:39523
480108
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coenzyme Q8A
Macaque
coenzyme Q8A
Mouse
Rat
Dog
coenzyme Q8A
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NI60-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Cofactor biosynthesis; ubiquinone biosynthesis.
Name
Explore in Pharos
Explore in Source
Cofactor biosynthesis; ubiquinone biosynthesis.
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (70)
1 – 10 of 70
DOK2
Tbio
Novelty:  0.02651438
p_int:  0.959037018
p_ni:  0.040962982
Score:  0.297
Data Source:  BioPlex,STRINGDB
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
p_int:  0.944761949
p_ni:  0.055237956
p_wrong:  9.5e-8
Score:  0.22
Data Source:  BioPlex,STRINGDB
COQ9
Tbio
Novelty:  0.00740475
Score:  0.969
Data Source:  STRINGDB
COQ3
Tbio
Family:  Enzyme
Novelty:  0.03013258
Score:  0.959
Data Source:  STRINGDB
COQ5
Tbio
Family:  Enzyme
Novelty:  0.04664953
Score:  0.953
Data Source:  STRINGDB
COQ4
Tbio
Novelty:  0.03537017
Score:  0.939
Data Source:  STRINGDB
COQ7
Tbio
Family:  Enzyme
Novelty:  0.01010794
Score:  0.934
Data Source:  STRINGDB
PDSS1
Tbio
Family:  Enzyme
Novelty:  0.01542427
Score:  0.93
Data Source:  STRINGDB
COQ6
Tbio
Family:  Enzyme
Novelty:  0.0290336
Score:  0.926
Data Source:  STRINGDB
COQ2
Tbio
Family:  Enzyme
Novelty:  0.00575853
Score:  0.925
Data Source:  STRINGDB
Publication Statistics
PubMed Score  64.99

PubMed score by year
PubTator Score  25.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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