Tbio CTCFL Transcriptional repressor CTCFL

Protein Summary

Description

Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• Q8NI51
• A0S6W1
• A1L4C6
• A6XGL8
• A6XGM2
• A6XGM3
• A6XGM8
• A6XGN0
• A6XGN1
• A6XGN2
• A6XGN3
• A6XGN4
• E7EQ27
• E7EUE3
• E9PBA9
• Q5JUG4
• Q9BZ30
• Q9NQJ3

Gene Name

• CTCFL

Ensembl ID

• ENST00000243914
• ENSP00000243914
• ENSG00000124092
• ENST00000371196
• ENSP00000360239
• ENST00000422109
• ENSP00000413713
• ENST00000422869
• ENSP00000399061
• ENST00000423479
• ENSP00000415579
• ENST00000429804
• ENSP00000415329
• ENST00000432255
• ENSP00000409344
• ENST00000433949
• ENSP00000392034
• ENST00000502686
• ENSP00000437999
• ENST00000539382
• ENSP00000439998
• ENST00000608263
• ENSP00000476783
• ENST00000608440
• ENSP00000477488
• ENST00000608903
• ENSP00000476718
• ENST00000609232
• ENSP00000476398

Symbol

• BORIS
• CT27
• BORIS
• CTCF-T
• HMGB1L1
• dJ579F20.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
biological process	0.76
microRNA	0.68
transcription factor	0.62
biological term	0.61

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Transcriptional Repressor Ctcfl

Protein / ... / Krab Box Transcription Factor / Transcriptional Repressor Ctcfl

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Transcriptional Repressor Ctcfl

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.38   (req: < 5)

Gene RIFs: 71   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.38   (req: >= 5)

Gene RIFs: 71   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0