CTCFL
Transcriptional repressor CTCFL
Protein Summary
Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive i ...more
- ENST00000243914
- ENSP00000243914
- ENSG00000124092
- ENST00000371196
- ENSP00000360239
- ENST00000422109
- ENSP00000413713
- ENST00000422869
- ENSP00000399061
- ENST00000423479
- ENSP00000415579
- ENST00000429804
- ENSP00000415329
- ENST00000432255
- ENSP00000409344
- ENST00000433949
- ENSP00000392034
- ENST00000502686
- ENSP00000437999
- ENST00000539382
- ENSP00000439998
- ENST00000608263
- ENSP00000476783
- ENST00000608440
- ENSP00000477488
- ENST00000608903
- ENSP00000476718
- ENST00000609232
- ENSP00000476398
- BORIS
- CT27
- BORIS
- CTCF-T
- HMGB1L1
- dJ579F20.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.88 | ||
biological process | 0.76 | ||
microRNA | 0.68 | ||
transcription factor | 0.62 | ||
biological term | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 90.38 (req: < 5)
Gene RIFs: 71 (req: <= 3)
Antibodies: 222 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 90.38 (req: >= 5)
Gene RIFs: 71 (req: > 3)
Antibodies: 222 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0