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Tbio
CTCFL
Transcriptional repressor CTCFL

Protein Summary
Description
Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243914
  • ENSP00000243914
  • ENSG00000124092
  • ENST00000371196
  • ENSP00000360239
  • ENST00000422109
  • ENSP00000413713
  • ENST00000422869
  • ENSP00000399061
  • ENST00000423479
  • ENSP00000415579
  • ENST00000429804
  • ENSP00000415329
  • ENST00000432255
  • ENSP00000409344
  • ENST00000433949
  • ENSP00000392034
  • ENST00000502686
  • ENSP00000437999
  • ENST00000539382
  • ENSP00000439998
  • ENST00000608263
  • ENSP00000476783
  • ENST00000608440
  • ENSP00000477488
  • ENST00000608903
  • ENSP00000476718
  • ENST00000609232
  • ENSP00000476398

Symbol
  • BORIS
  • CT27
  • BORIS
  • CTCF-T
  • HMGB1L1
  • dJ579F20.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
biological process
0.76
microRNA
0.68
transcription factor
0.62
biological term
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.1   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.1   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
81.9
triglyceride measurement
3
2
3
81.4
BMI-adjusted waist-hip ratio
1
1
1
39.9
waist-hip ratio
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
81.9
triglyceride measurement
3
81.4
BMI-adjusted waist-hip ratio
1
39.9
waist-hip ratio
1
17.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
CCCTC-binding factor like
701500
Mouse
MGI:3652571
664799
Rat
RGD:2321501
100360757
Dog
CCCTC-binding factor like
VGNC:54644
477271
Horse
CCCTC-binding factor like
VGNC:16929
100055665
Species
Name
OMA
EggNOG
Inparanoid
Macaque
CCCTC-binding factor like
Mouse
Rat
Dog
CCCTC-binding factor like
Horse
CCCTC-binding factor like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NI51-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (18)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (64)
1 – 10 of 64
PRMT7
Tchem
Family: Epigenetic
Novelty: 0.02310897
Score: 0.815
Data Source: STRINGDB
IGF2
Tbio
Novelty: 0.00021277
Score: 0.803
Data Source: STRINGDB
RAD21
Tbio
Novelty: 0.00270936
Score: 0.734
Data Source: STRINGDB
RAD21L1
Tdark
Novelty: 0.11750397
Score: 0.716
Data Source: STRINGDB
SMC3
Tbio
Novelty: 0.00474377
Score: 0.707
Data Source: STRINGDB
RBM38
Tbio
Novelty: 0.03491566
Score: 0.695
Data Source: STRINGDB
PHACTR3
Tbio
Family: Enzyme
Novelty: 0.09524691
Score: 0.669
Data Source: STRINGDB
CHD8
Tbio
Family: Epigenetic
Novelty: 0.01177693
Score: 0.656
Data Source: STRINGDB
COX7A1
Tbio
Family: Enzyme
Novelty: 0.02514171
Score: 0.641
Data Source: STRINGDB
CBLN4
Tbio
Novelty: 0.11296355
Score: 0.64
Data Source: STRINGDB
Publication Statistics
PubMed Score  70.10

PubMed score by year
PubTator Score  119.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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