Tbio CTCFL Transcriptional repressor CTCFL

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Transcriptional Repressor Ctcfl

Protein / ... / Krab Box Transcription Factor / Transcriptional Repressor Ctcfl

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Transcriptional Repressor Ctcfl

Protein Summary

Description

Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• Q8NI51
• A0S6W1
• A1L4C6
• A6XGL8
• A6XGM2
• A6XGM3
• A6XGM8
• A6XGN0
• A6XGN1
• A6XGN2
• A6XGN3
• A6XGN4
• E7EQ27
• E7EUE3
• E9PBA9
• Q5JUG4
• Q9BZ30
• Q9NQJ3

Gene Name

• CTCFL

Ensembl ID

• ENST00000243914
• ENSP00000243914
• ENSG00000124092
• ENST00000371196
• ENSP00000360239
• ENST00000422109
• ENSP00000413713
• ENST00000422869
• ENSP00000399061
• ENST00000423479
• ENSP00000415579
• ENST00000429804
• ENSP00000415329
• ENST00000432255
• ENSP00000409344
• ENST00000433949
• ENSP00000392034
• ENST00000502686
• ENSP00000437999
• ENST00000539382
• ENSP00000439998
• ENST00000608263
• ENSP00000476783
• ENST00000608440
• ENSP00000477488
• ENST00000608903
• ENSP00000476718
• ENST00000609232
• ENSP00000476398

Symbol

• BORIS
• CT27
• BORIS
• CTCF-T
• HMGB1L1
• dJ579F20.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
biological process	0.76
microRNA	0.68
transcription factor	0.62
biological term	0.61

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.1   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.1   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	2	2	2		81.9
triglyceride measurement	EFO_0004530	3	2	3		81.4
BMI-adjusted waist-hip ratio	EFO_0007788	1	1	1		39.9
waist-hip ratio	EFO_0004343	1	1	1		17.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	2		81.9
triglyceride measurement	EFO_0004530	3		81.4
BMI-adjusted waist-hip ratio	EFO_0007788	1		39.9
waist-hip ratio	EFO_0004343	1		17.8

Reset Zoom  Beta Count   Odds Ratio

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	CCCTC-binding factor like		701500
Mouse	CCCTC-binding factor (zinc finger protein)-like	MGI:3652571	664799
Rat	CCCTC-binding factor like	RGD:2321501	100360757
Dog	CCCTC-binding factor like	VGNC:54644	477271
Horse	CCCTC-binding factor like	VGNC:16929	100055665

Species	Name	OMA	EggNOG	Inparanoid
Macaque	CCCTC-binding factor like
Mouse	CCCTC-binding factor (zinc finger protein)-like
Rat	CCCTC-binding factor like
Dog	CCCTC-binding factor like
Horse	CCCTC-binding factor like

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q8NI51-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (18)

Functions (8)

Components (2)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
histone binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
sequence-specific DNA binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (64)

Explore Interacting Targets

1 – 10 of 64

• See Interactions on String-DB

PRMT7

Tchem

Family: Epigenetic

Novelty: 0.02310897

Score: 0.815

Data Source: STRINGDB

IGF2

Tbio

Novelty: 0.00021277

Score: 0.803

Data Source: STRINGDB

RAD21

Tbio

Novelty: 0.00270936

Score: 0.734

Data Source: STRINGDB

RAD21L1

Tdark

Novelty: 0.11750397

Score: 0.716

Data Source: STRINGDB

SMC3

Tbio

Novelty: 0.00474377

Score: 0.707

Data Source: STRINGDB

RBM38

Tbio

Novelty: 0.03491566

Score: 0.695

Data Source: STRINGDB

PHACTR3

Tbio

Family: Enzyme

Novelty: 0.09524691

Score: 0.669

Data Source: STRINGDB

CHD8

Tbio

Family: Epigenetic

Novelty: 0.01177693

Score: 0.656

Data Source: STRINGDB

COX7A1

Tbio

Family: Enzyme

Novelty: 0.02514171

Score: 0.641

Data Source: STRINGDB

CBLN4

Tbio

Novelty: 0.11296355

Score: 0.64

Data Source: STRINGDB

Publication Statistics

PubMed Score  70.10

PubMed score by year

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PubTator Score  119.42

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Find similar targets by:

UniProt Keyword Find Similar Targets

Activator
Alternative splicing
Cell cycle
Chromatin regulator
Complete proteome
Cytoplasm
DNA-binding
Metal-binding
Nucleus
Polymorphism

GWAS Trait Find Similar Targets

BMI-adjusted waist-hip ratio
hemoglobin measurement
triglyceride measurement
waist-hip ratio

MGI Phenotype Find Similar Targets

cellular phenotype
endocrine/exocrine gland phenotype
reproductive system phenotype