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Tbio
NFKBID
NF-kappa-B inhibitor delta

Protein Summary
Description
Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396901
  • ENSP00000380109
  • ENSG00000167604
  • ENST00000606253
  • ENSP00000475712

Symbol
  • IKBNS
  • IkBNS
  • TA-NFKBH
  • IkappaBNS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
biological process
0.68
histone modification site profile
0.67
tissue sample
0.65
phenotype
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.04   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.04   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0