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Tbio
WDR36
WD repeat-containing protein 36

Protein Summary
Description
Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000506538
  • ENSP00000423067
  • ENSG00000134987
  • ENST00000612402
  • ENSP00000479950

Symbol
  • GLC1G
  • UTP21
  • TAWDRP
  • TA-WDRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
protein complex
0.9
kinase perturbation
0.84
cell type or tissue
0.73
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.75   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.75   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
10
1
1.1
98.6
eosinophil count
3
4
6
97.6
eosinophil percentage of leukocytes
2
4
5
94
7
3
3
1.1
93.1
childhood onset asthma
2
2
0
1.2
88.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
98.6
eosinophil count
6
97.6
eosinophil percentage of leukocytes
5
94
3
1.1
93.1
childhood onset asthma
0
1.2
88.7
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 36
VGNC:4222
461989
Macaque
WD repeat domain 36
706420
Mouse
MGI:1917819
225348
Rat
RGD:1586463
688637
Dog
WD repeat domain 36
VGNC:48363
488875
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 36
Macaque
WD repeat domain 36
Mouse
Rat
Dog
WD repeat domain 36
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NI36-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (381)
1 – 10 of 381
WDR3
Tbio
Novelty:  0.15410886
p_int:  0.999999273
p_ni:  7.27e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
PWP2
Tbio
Novelty:  0.04910741
p_int:  0.999940188
p_ni:  0.000059812
Score:  0.999
Data Source:  BioPlex,STRINGDB
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.999765265
p_ni:  0.00023473
p_wrong:  5e-9
Score:  0.904
Data Source:  BioPlex,STRINGDB
TBL3
Tdark
Novelty:  0.05195885
p_int:  0.999415082
p_ni:  0.000584916
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
HMMR
Tchem
Novelty:  0.0039196
p_int:  0.999347547
p_ni:  0.000652453
Data Source:  BioPlex
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.998647085
p_ni:  0.001352915
Score:  0.998
Data Source:  BioPlex,STRINGDB
RBM4
Tbio
Novelty:  0.02034191
p_int:  0.998030079
p_ni:  0.001969896
p_wrong:  2.5e-8
Data Source:  BioPlex
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.989664555
p_ni:  0.010335143
p_wrong:  3.02e-7
Data Source:  BioPlex
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.986163679
p_ni:  0.013836255
p_wrong:  6.7e-8
Score:  0.152
Data Source:  BioPlex,STRINGDB
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.981428144
p_ni:  0.01857168
p_wrong:  1.75e-7
Data Source:  BioPlex
Publication Statistics
PubMed Score  42.75

PubMed score by year
PubTator Score  31.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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