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Tdark
LYPD6B
Ly6/PLAUR domain-containing protein 6B

Protein Summary
Description
Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409029
  • ENSP00000386650
  • ENSG00000150556
  • ENST00000409642
  • ENSP00000387077
  • ENST00000409876
  • ENSP00000386479

Symbol
  • CT116
  • LYPD7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.78
PubMedID
0.61
transcription factor binding site profile
0.56
transcription factor
0.55
tissue
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.51   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.51   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
IDE
Tchem
Family:  Enzyme
Novelty:  0.00207793
p_int:  0.999774099
p_ni:  0.000225901
Data Source:  BioPlex
PSME4
Tbio
Novelty:  0.01206213
p_int:  0.99936513
p_ni:  0.00063487
Data Source:  BioPlex
KCMF1
Tbio
Family:  Enzyme
Novelty:  0.05485534
p_int:  0.993710774
p_ni:  0.006289226
Data Source:  BioPlex
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.993585846
p_ni:  0.006414154
Data Source:  BioPlex
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.971734721
p_ni:  0.02826528
Data Source:  BioPlex
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
p_int:  0.95405394
p_ni:  0.04594606
Data Source:  BioPlex
PLXDC2
Tbio
Novelty:  0.06496695
p_int:  0.808581127
p_ni:  0.191418873
Data Source:  BioPlex
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.753480822
p_ni:  0.246519178
Data Source:  BioPlex
LY6H
Tbio
Novelty:  0.10210816
Score:  0.949
Data Source:  STRINGDB
LYPD5
Tdark
Novelty:  0.97576337
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
4
0
8.8
89.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
8.8
89.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LY6/PLAUR domain containing 6B
VGNC:1993
470558
Macaque
LY6/PLAUR domain containing 6B
693727
Mouse
MGI:1919147
71897
Rat
RGD:1562767
362133
Dog
LY6/PLAUR domain containing 6B
100686612
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LY6/PLAUR domain containing 6B
Macaque
LY6/PLAUR domain containing 6B
Mouse
Rat
Dog
LY6/PLAUR domain containing 6B
Publication Statistics
PubMed Score 7.51
PubMed score by year
PubTator Score 2.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title