You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CDC26
Anaphase-promoting complex subunit CDC26

Protein Summary
Description
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374206
  • ENSP00000363322
  • ENSG00000176386

Symbol
  • ANAPC12
  • C9orf17
  • APC12
  • ANAPC12
  • C9orf17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
biological process
0.94
histone modification site profile
0.89
transcription factor binding site profile
0.76
tissue sample
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.05   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.05   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (384)
ANAPC2
Tbio
Family:  Enzyme
Novelty:  0.19812984
p_int:  0.999999941
p_ni:  5.9e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC4
Tbio
Family:  Enzyme
Novelty:  0.28937094
p_int:  0.99999979
p_ni:  2.1e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC13
Tbio
Family:  Enzyme
Novelty:  0.06125489
p_int:  0.999999684
p_ni:  3.16e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.999999157
p_ni:  8.43e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
FBXO5
Tbio
Novelty:  0.01571484
p_int:  0.999998323
p_ni:  0.000001677
Score:  0.991
Data Source:  BioPlex,STRINGDB
CDC27
Tbio
Novelty:  0.00589846
p_int:  0.999998104
p_ni:  0.000001896
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC23
Tbio
Novelty:  0.0168525
p_int:  0.999997546
p_ni:  0.000002454
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC5
Tbio
Family:  Enzyme
Novelty:  0.02102572
p_int:  0.999995545
p_ni:  0.000004171
p_wrong:  2.84e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC16
Tdark
Family:  Enzyme
Novelty:  0.06353035
p_int:  0.999978285
p_ni:  0.000021584
p_wrong:  1.33e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC1
Tbio
Family:  Enzyme
Novelty:  0.0521845
p_int:  0.999954882
p_ni:  0.000045118
Score:  0.999
Data Source:  BioPlex,STRINGDB
Pathways (43)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
81.3
myeloid white cell count
1
1
1
61.4
leukocyte count
1
1
1
48.5
neutrophil percentage of leukocytes
1
1
1
29
monocyte percentage of leukocytes
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
81.3
myeloid white cell count
1
61.4
leukocyte count
1
48.5
neutrophil percentage of leukocytes
1
29
monocyte percentage of leukocytes
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 26
VGNC:4655
473026
Macaque
cell division cycle 26
706165
Mouse
MGI:1913690
66440
Rat
RGD:1311342
366381
Dog
cell division cycle 26
VGNC:38992
481679
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 26
Macaque
cell division cycle 26
Mouse
Rat
Dog
cell division cycle 26
Publication Statistics
PubMed Score 12.05
PubMed score by year
PubTator Score 5.56
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title