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Tbio
ZFP28
Zinc finger protein 28 homolog

Protein Summary
Description
May be involved in transcriptional regulation. May have a role in embryonic development.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301318
  • ENSP00000301318
  • ENSG00000196867
  • ENST00000591844
  • ENSP00000468603

Symbol
  • KIAA1431
  • mkr5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
protein domain
0.58
transcription factor perturbation
0.54
gene perturbation
0.5
microRNA
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.56   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.56   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
1
1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
11.6
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ZFP28 zinc finger protein
VGNC:7616
456320
Macaque
ZFP28 zinc finger protein
100425275
Mouse
MGI:99175
22690
Rat
RGD:7679103
102548693
Cow
ZFP28 zinc finger protein
VGNC:37160
100301148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ZFP28 zinc finger protein
Macaque
ZFP28 zinc finger protein
Mouse
Rat
Cow
ZFP28 zinc finger protein
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NHY6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Protein-Protein Interactions (27)
1 – 10 of 27
TRIM28
Tbio
Family: Epigenetic
Novelty: 0.00778381
Score: 0.909
Data Source: STRINGDB
CCDC43
Tdark
Novelty: 0.99040074
Score: 0.626
Data Source: STRINGDB
C2CD4C
Tdark
Novelty: 0.74998413
Score: 0.551
Data Source: STRINGDB
ELFN2
Tdark
Family: Enzyme
Novelty: 0.40013413
Score: 0.548
Data Source: STRINGDB
DISP3
Tbio
Novelty: 0.09299918
Score: 0.525
Data Source: STRINGDB
PHACTR2
Tbio
Family: Enzyme
Novelty: 0.25056698
Score: 0.524
Data Source: STRINGDB
ZC3H3
Tbio
Novelty: 0.26894046
Score: 0.518
Data Source: STRINGDB
PPP1R18
Tbio
Novelty: 0.18837599
Score: 0.517
Data Source: STRINGDB
PUM3
Tbio
Novelty: 0.02344206
Score: 0.51
Data Source: STRINGDB
ARHGAP45
Tbio
Novelty: 0.13518861
Score: 0.497
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.56

PubMed score by year
PubTator Score  1.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer