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Tbio
COP1
E3 ubiquitin-protein ligase COP1

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308769
  • ENSP00000310943
  • ENSG00000143207
  • ENST00000367669
  • ENSP00000356641
  • ENST00000474194
  • ENSP00000433517

Symbol
  • RFWD2
  • RNF200
  • RFWD2
  • RNF200
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.56   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.56   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
3
3
2
1
85.4
1
2
2
38.1
cigarettes per day measurement
2
1
2
35
major depressive disorder
1
1
1
31.4
BMI-adjusted hip circumference
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
2
1
85.4
2
38.1
cigarettes per day measurement
2
35
major depressive disorder
1
31.4
BMI-adjusted hip circumference
1
21.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
COP1, E3 ubiquitin ligase
VGNC:9457
457541
Mouse
MGI:1347046
26374
Dog
COP1, E3 ubiquitin ligase
VGNC:53338
480060
Horse
COP1, E3 ubiquitin ligase
VGNC:49339
100061855
Cow
COP1, E3 ubiquitin ligase
VGNC:50041
519896
Species
Name
OMA
EggNOG
Inparanoid
Chimp
COP1, E3 ubiquitin ligase
Mouse
Dog
COP1, E3 ubiquitin ligase
Horse
COP1, E3 ubiquitin ligase
Cow
COP1, E3 ubiquitin ligase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NHY2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (234)
1 – 10 of 234
DET1
Tbio
Novelty:  0.01138079
p_int:  0.999999998
p_ni:  2e-9
Score:  0.979
Data Source:  BioPlex,STRINGDB
STK40
Tbio
Family:  Kinase
Novelty:  0.10461675
p_int:  0.999999429
p_ni:  5.71e-7
Score:  0.944
Data Source:  BioPlex,STRINGDB
TRIB2
Tbio
Family:  Kinase
Novelty:  0.02240668
p_int:  0.999998797
p_ni:  0.000001202
p_wrong:  1e-9
Score:  0.775
Data Source:  BioPlex,STRINGDB
SEPSECS
Tbio
Family:  Enzyme
Novelty:  0.00698701
p_int:  0.999998722
p_ni:  0.000001063
p_wrong:  2.15e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
TRIB1
Tbio
Family:  Kinase
Novelty:  0.01587891
p_int:  0.999997984
p_ni:  0.000002016
Score:  0.857
Data Source:  BioPlex,STRINGDB
SPOP
Tbio
Novelty:  0.00663363
p_int:  0.999996176
p_ni:  0.000003824
Score:  0.158
Data Source:  BioPlex,STRINGDB
ETV5
Tbio
Family:  TF
Novelty:  0.00052506
p_int:  0.999994048
p_ni:  0.000005951
Score:  0.852
Data Source:  BioPlex,STRINGDB
FAM120B
Tbio
Novelty:  0.07982799
p_int:  0.999992807
p_ni:  0.000007193
Score:  0.183
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.99999155
p_ni:  0.00000845
Score:  0.189
Data Source:  BioPlex,STRINGDB
WASHC1
Tbio
Novelty:  0.09242196
p_int:  0.999987845
p_ni:  0.000012153
p_wrong:  1e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  9.56

PubMed score by year
PubTator Score  138.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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