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Tbio
B4GALNT2
Beta-1,4 N-acetylgalactosaminyltransferase 2

Protein Summary
Description
Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain. B4GALNT2 catalyzes the last step in the biosynthesis of the human Sd(a) antigen through the addition of an N-acetylgalactosamine residue via a beta-1,4 linkage to a subterminal galactose residue substituted with an alpha-2,3-linked sialic acid. B4GALNT2 also catalyzes the last step in the biosynthesis of the Cad antigen (Montiel et al., 2003 [PubMed 12678917]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300404
  • ENSP00000300404
  • ENSG00000167080
  • ENST00000393354
  • ENSP00000377022
  • ENST00000504681
  • ENSP00000425510

Symbol
  • GALGT2
  • B4GALT
  • GALGT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.73
cell line
0.66
disease perturbation
0.56
transcription factor
0.52
disease
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.01   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.01   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (60)
1 – 10 of 60
UMOD
Tbio
Novelty:  0.00153334
Score:  0.947
Data Source:  Reactome,STRINGDB
ST8SIA5
Tdark
Family:  Enzyme
Novelty:  0.19468906
Score:  0.755
Data Source:  STRINGDB
ST6GALNAC6
Tdark
Family:  Enzyme
Novelty:  0.18823446
Score:  0.755
Data Source:  STRINGDB
VWF
Tclin
Novelty:  0.00009007
Score:  0.751
Data Source:  STRINGDB
ST3GAL2
Tbio
Family:  Enzyme
Novelty:  0.03503891
Score:  0.743
Data Source:  STRINGDB
ST3GAL5
Tbio
Family:  Enzyme
Novelty:  0.01407498
Score:  0.723
Data Source:  STRINGDB
ST6GAL2
Tbio
Family:  Enzyme
Novelty:  0.02408727
Score:  0.717
Data Source:  STRINGDB
ST8SIA6
Tbio
Family:  Enzyme
Novelty:  0.1607229
Score:  0.713
Data Source:  STRINGDB
ST3GAL3
Tbio
Family:  Enzyme
Novelty:  0.01592595
Score:  0.712
Data Source:  STRINGDB
ST3GAL6
Tbio
Family:  Enzyme
Novelty:  0.05226811
Score:  0.712
Data Source:  STRINGDB
Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Blood group systems biosynthesis
Reactome
Lewis blood group biosynthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Blood group systems biosynthesis
Lewis blood group biosynthesis
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
3
2
6.3
88.2
2
1
0
1.1
51.4
testosterone measurement
1
1
1
49.5
monocyte percentage of leukocytes
1
1
1
47.7
BMI-adjusted hip circumference
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
6.3
88.2
0
1.1
51.4
testosterone measurement
1
49.5
monocyte percentage of leukocytes
1
47.7
BMI-adjusted hip circumference
1
47.7
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-N-acetyl-galactosaminyltransferase 2
VGNC:9130
750651
Macaque
beta-1,4-N-acetyl-galactosaminyltransferase 2
700278
Mouse
MGI:1342058
14422
Dog
beta-1,4-N-acetyl-galactosaminyltransferase 2
VGNC:38346
491067
Horse
beta-1,4-N-acetyl-galactosaminyltransferase 2
VGNC:53708
100069631
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-N-acetyl-galactosaminyltransferase 2
Macaque
beta-1,4-N-acetyl-galactosaminyltransferase 2
Mouse
Dog
beta-1,4-N-acetyl-galactosaminyltransferase 2
Horse
beta-1,4-N-acetyl-galactosaminyltransferase 2
Publication Statistics
PubMed Score 215.01
PubMed score by year
PubTator Score 15.90
PubTator score by year