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Tchem
TPCN2
Two pore calcium channel protein 2

Protein Summary
Description
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294309
  • ENSP00000294309
  • ENSG00000162341

Symbol
  • TPC2
  • TPC2
  • SHEP10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
cell line
0.59
cellular component
0.56
histone modification site profile
0.56
biological process
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.21   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.21   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
verapamil
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
6
7
0
1.6
99
heel bone mineral density
3
2
6
96.7
hair colour measurement
1
1
1
89.7
suntan
1
1
1
82.3
2
2
1
1.1
69.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.6
99
heel bone mineral density
6
96.7
hair colour measurement
1
89.7
suntan
1
82.3
1
1.1
69.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
two pore segment channel 2
VGNC:53181
747605
Macaque
two pore segment channel 2
709391
Mouse
MGI:2385297
233979
Rat
RGD:1311779
309139
Dog
two pore segment channel 2
VGNC:47733
483683
Species
Name
OMA
EggNOG
Inparanoid
Chimp
two pore segment channel 2
Macaque
two pore segment channel 2
Mouse
Rat
Dog
two pore segment channel 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NHX9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Protein-Protein Interactions (102)
1 – 10 of 102
TMEM154
Tdark
Novelty: 0.08935925
p_int: 0.999999544
p_ni: 4.56e-7
Data Source: BioPlex
ANKRD27
Tbio
Novelty: 0.02843267
p_int: 0.999997386
p_ni: 0.000002611
p_wrong: 2e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
AGBL5
Tbio
Family: Enzyme
Novelty: 0.05735805
p_int: 0.999997229
p_ni: 0.000002771
Data Source: BioPlex
USP32
Tbio
Family: Enzyme
Novelty: 0.08043957
p_int: 0.99992695
p_ni: 0.00007305
Score: 0.301
Data Source: BioPlex,STRINGDB
DENND6A
Tbio
Novelty: 4.5572617
p_int: 0.999695866
p_ni: 0.000304134
Data Source: BioPlex
TRAPPC8
Tdark
Novelty: 0.07711264
p_int: 0.999244102
p_ni: 0.000755898
Score: 0.174
Data Source: BioPlex,STRINGDB
WDR44
Tdark
Novelty: 0.02158824
p_int: 0.998743296
p_ni: 0.001256704
Data Source: BioPlex
PTPRA
Tchem
Family: Enzyme
Novelty: 0.01392344
p_int: 0.998536699
p_ni: 0.000027812
p_wrong: 0.001435488
Score: 0.158
Data Source: BioPlex,STRINGDB
CLCN3
Tchem
Family: IC
Novelty: 0.00416196
p_int: 0.997947216
p_ni: 0.002045274
p_wrong: 0.00000751
Score: 0.172
Data Source: BioPlex,STRINGDB
FBXO10
Tbio
Novelty: 0.18324932
p_int: 0.99694949
p_ni: 0.002653057
p_wrong: 0.000397453
Data Source: BioPlex
Publication Statistics
PubMed Score  93.21

PubMed score by year
PubTator Score  43.02

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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