TPCN2
Two pore calcium channel protein 2
Protein Summary
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]
- ENST00000294309
- ENSP00000294309
- ENSG00000162341
- TPC2
- TPC2
- SHEP10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
cell line | 0.59 | ||
cellular component | 0.56 | ||
histone modification site profile | 0.56 | ||
biological process | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.18 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.18 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (1)
Protein-Protein Interactions (102)
ANKRD27
Novelty: 0.02843267
p_int: 0.999997386
p_ni: 0.000002611
p_wrong: 2e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
AGBL5
Family: Enzyme
Novelty: 0.05735805
p_int: 0.999997229
p_ni: 0.000002771
Data Source: BioPlex
USP32
Family: Enzyme
Novelty: 0.08043957
p_int: 0.99992695
p_ni: 0.00007305
Score: 0.301
Data Source: BioPlex,STRINGDB
TRAPPC8
Novelty: 0.07711264
p_int: 0.999244102
p_ni: 0.000755898
Score: 0.174
Data Source: BioPlex,STRINGDB
PTPRA
Family: Enzyme
Novelty: 0.01392344
p_int: 0.998536699
p_ni: 0.000027812
p_wrong: 0.001435488
Score: 0.158
Data Source: BioPlex,STRINGDB
CLCN3
Family: IC
Novelty: 0.00416196
p_int: 0.997947216
p_ni: 0.002045274
p_wrong: 0.00000751
Score: 0.172
Data Source: BioPlex,STRINGDB
FBXO10
Novelty: 0.18324932
p_int: 0.99694949
p_ni: 0.002653057
p_wrong: 0.000397453
Data Source: BioPlex
Nearest Tclin Targets
Pathways (8)
Reactome (3)
KEGG (2)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ion channel transport | ||||
Reactome | Stimuli-sensing channels | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ion channel transport | ||||
Stimuli-sensing channels | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (4)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hair color | 6 | 7 | 0 | 1.6 | 99.6 | ||||
12 | 8 | 1 | 1.2 | 98.1 | |||||
heel bone mineral density | 3 | 2 | 6 | 93.7 | |||||
hair colour measurement | 1 | 1 | 1 | 87.2 | |||||
BMI-adjusted hip circumference | 2 | 9 | 10 | 84.1 | |||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hair color | 0 | 1.6 | 99.6 | ||||
1 | 1.2 | 98.1 | |||||
heel bone mineral density | 6 | 93.7 | |||||
hair colour measurement | 1 | 87.2 | |||||
BMI-adjusted hip circumference | 10 | 84.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | two pore segment channel 2 | VGNC:53181 | 747605 | |||||
Macaque | two pore segment channel 2 | 709391 | ||||||
Mouse | MGI:2385297 | 233979 | ||||||
Rat | RGD:1311779 | 309139 | ||||||
Dog | two pore segment channel 2 | VGNC:47733 | 483683 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | two pore segment channel 2 | |||||
Macaque | two pore segment channel 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | two pore segment channel 2 | |||||
Publication Statistics
PubMed Score 99.18
PubMed score by year
PubTator Score 43.02
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (37)
GeneRif Annotations (24)
Items per page:
0 of 0
PMID | Year | Title |
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