You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CCL4L1
C-C motif chemokine 4-like

Protein Summary
Description
Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5. This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610565
  • ENSP00000484498
  • ENSG00000276070
  • ENST00000613173
  • ENSP00000484455
  • ENST00000613828
  • ENSP00000484322
  • ENSG00000282604
  • ENST00000614182
  • ENSP00000482862
  • ENSG00000276125
  • ENST00000615418
  • ENSP00000483206
  • ENST00000616100
  • ENSP00000484148
  • ENST00000617405
  • ENSP00000483330
  • ENST00000617416
  • ENSP00000480089
  • ENST00000620055
  • ENSP00000481323
  • ENST00000620063
  • ENSP00000478376
  • ENST00000620098
  • ENSP00000479774
  • ENST00000620250
  • ENSP00000483609
  • ENST00000620576
  • ENSP00000479354
  • ENST00000620708
  • ENSP00000479126
  • ENSG00000275313
  • ENST00000620732
  • ENSP00000481969
  • ENST00000622783
  • ENSP00000479833
  • ENST00000631554
  • ENSP00000487911
  • ENST00000631660
  • ENSP00000488687
  • ENST00000631768
  • ENSP00000488094
  • ENST00000631782
  • ENSP00000488541
  • ENST00000631808
  • ENSP00000487651
  • ENST00000632416
  • ENSP00000487859
  • ENST00000632480
  • ENSP00000488369
  • ENST00000632699
  • ENSP00000488366
  • ENST00000632710
  • ENSP00000488758
  • ENST00000633309
  • ENSP00000488719
  • ENST00000633550
  • ENSP00000488736
  • ENST00000633849
  • ENSP00000487792
  • ENST00000633897
  • ENSP00000488897
  • ENST00000633927
  • ENSP00000488430
  • ENST00000634027
  • ENSP00000488439
  • ENST00000634078
  • ENSP00000488231
  • ENST00000634191
  • ENSP00000487715

Symbol
  • CCL4L
  • LAG1
  • SCYA4L1
  • LAG1
  • CCL4L
  • LAG-1
  • SCYA4L
  • AT744.2
  • SCYA4L1
  • SCYA4L2
  • MIP-1-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.85
disease
0.62
tissue
0.47
phenotype
0.46
biological term
0.39


Related Tools
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 475.58   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 475.58   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NHW4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (268)
1 – 10 of 268
CCR5
Tclin
Family: GPCR
Novelty: 0.00022549
Score: 0.98
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.978
Data Source: STRINGDB
CXCL13
Tbio
Novelty: 0.00118688
Score: 0.977
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.976
Data Source: STRINGDB
CCR1
Tchem
Family: GPCR
Novelty: 0.00218065
Score: 0.967
Data Source: STRINGDB
CCR2
Tchem
Family: GPCR
Novelty: 0.0006525
Score: 0.964
Data Source: STRINGDB
CCR3
Tchem
Family: GPCR
Novelty: 0.00197059
Score: 0.963
Data Source: STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.962
Data Source: STRINGDB
CXCL1
Tbio
Novelty: 0.00059123
Score: 0.96
Data Source: STRINGDB
CXCR4
Tclin
Family: GPCR
Novelty: 0.0002811
Score: 0.958
Data Source: STRINGDB
Publication Statistics
PubMed Score  475.58

PubMed score by year
PubTator Score  29.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer