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Tbio
CCL4L1
C-C motif chemokine 4-like

Protein Summary
Description
Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5. This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610565
  • ENSP00000484498
  • ENSG00000276070
  • ENST00000613173
  • ENSP00000484455
  • ENST00000613828
  • ENSP00000484322
  • ENSG00000282604
  • ENST00000614182
  • ENSP00000482862
  • ENSG00000276125
  • ENST00000615418
  • ENSP00000483206
  • ENST00000616100
  • ENSP00000484148
  • ENST00000617405
  • ENSP00000483330
  • ENST00000617416
  • ENSP00000480089
  • ENST00000620055
  • ENSP00000481323
  • ENST00000620063
  • ENSP00000478376
  • ENST00000620098
  • ENSP00000479774
  • ENST00000620250
  • ENSP00000483609
  • ENST00000620576
  • ENSP00000479354
  • ENST00000620708
  • ENSP00000479126
  • ENSG00000275313
  • ENST00000620732
  • ENSP00000481969
  • ENST00000622783
  • ENSP00000479833
  • ENST00000631554
  • ENSP00000487911
  • ENST00000631660
  • ENSP00000488687
  • ENST00000631768
  • ENSP00000488094
  • ENST00000631782
  • ENSP00000488541
  • ENST00000631808
  • ENSP00000487651
  • ENST00000632416
  • ENSP00000487859
  • ENST00000632480
  • ENSP00000488369
  • ENST00000632699
  • ENSP00000488366
  • ENST00000632710
  • ENSP00000488758
  • ENST00000633309
  • ENSP00000488719
  • ENST00000633550
  • ENSP00000488736
  • ENST00000633849
  • ENSP00000487792
  • ENST00000633897
  • ENSP00000488897
  • ENST00000633927
  • ENSP00000488430
  • ENST00000634027
  • ENSP00000488439
  • ENST00000634078
  • ENSP00000488231
  • ENST00000634191
  • ENSP00000487715

Symbol
  • CCL4L
  • LAG1
  • SCYA4L1
  • LAG1
  • CCL4L
  • LAG-1
  • SCYA4L
  • AT744.2
  • SCYA4L1
  • SCYA4L2
  • MIP-1-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.85
disease
0.62
tissue
0.47
phenotype
0.46
biological term
0.39


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.03   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.03   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (268)
CCR5
Tclin
Family:  GPCR
Novelty:  0.00022549
Score:  0.98
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.978
Data Source:  STRINGDB
CXCL13
Tbio
Novelty:  0.00118688
Score:  0.977
Data Source:  STRINGDB
CXCL8
Tchem
Novelty:  0.00005958
Score:  0.976
Data Source:  STRINGDB
CCR1
Tchem
Family:  GPCR
Novelty:  0.00218065
Score:  0.967
Data Source:  STRINGDB
CCR2
Tchem
Family:  GPCR
Novelty:  0.0006525
Score:  0.964
Data Source:  STRINGDB
CCR3
Tchem
Family:  GPCR
Novelty:  0.00197059
Score:  0.963
Data Source:  STRINGDB
CXCL9
Tbio
Novelty:  0.00073213
Score:  0.962
Data Source:  STRINGDB
CXCL1
Tbio
Novelty:  0.00059123
Score:  0.96
Data Source:  STRINGDB
CXCR4
Tclin
Family:  GPCR
Novelty:  0.0002811
Score:  0.958
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (18)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
2
2
87.5
macrophage inflammatory protein 1b measurement
1
2
2
87.5
macrophage inflammatory protein 1b measurement
1
2
2
87.5
CCL4 measurement
1
2
2
77.5
CCL4 measurement
1
2
2
77.5
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
2
87.5
macrophage inflammatory protein 1b measurement
2
87.5
macrophage inflammatory protein 1b measurement
2
87.5
CCL4 measurement
2
77.5
CCL4 measurement
2
77.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 484.03
PubMed score by year
PubTator Score 29.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title